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Mouse Anti-CRELD2 Recombinant Antibody (2B6) (CBMAB-C4712-LY)

This product is antibody recognizes CRELD2. The antibody 2B6 immunoassay techniques such as: ELISA, WB.
See all CRELD2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2B6
Antibody Isotype
IgM, κ
Application
ELISA, WB

Basic Information

Immunogen
CRELD2 (NP_077300, 162 a.a. ~ 258 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: GDGSCRCHMG YQGPLCTDCM DGYFSSLRNE THSICTACDE SCKTCSGLTN RDCGECEVGW VLDEGACVDV DECAAEPPPC SAAQFCKNAN GSYTCEE
Specificity
Human
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cysteine Rich With EGF Like Domains 2
Introduction
CRELD2 (Cysteine Rich With EGF Like Domains 2) is a Protein Coding gene. Diseases associated with CRELD2 include Multiple Epiphyseal Dysplasia. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CRELD1.
Entrez Gene ID
79174
UniProt ID
Q6UXH1
Alternative Names
Cysteine Rich With EGF Like Domains 2; Cysteine-Rich With EGF-Like Domains 2; Cysteine Rich With EGF-Like Domains 2;
Function
Protein disulfide isomerase (By similarity).

Might play a role in the unfolded protein response (By similarity).

May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (PubMed:16238698).
Cellular Location
Endoplasmic reticulum

Lasić, V., Kosović, I., Jurić, M., Racetin, A., Čurčić, J., Šolić, I., ... & Vukojević, K. (2021). GREB1L, CRELD2 and ITGA10 expression in the human developmental and postnatal kidneys: an immunohistochemical study. Acta Histochemica, 123(2), 151679.

Boyle, S. T., Poltavets, V., Kular, J., Pyne, N. T., Sandow, J. J., Lewis, A. C., ... & Samuel, M. S. (2020). ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism. Nature Cell Biology, 22(7), 882-895.

Dennis, E. P., Edwards, S. M., Jackson, R. M., Hartley, C. L., Tsompani, D., Capulli, M., ... & Briggs, M. D. (2020). CRELD2 is a novel LRP1 chaperone that regulates noncanonical WNT signaling in skeletal development. Journal of Bone and Mineral Research, 35(8), 1452-1469.

Chen, M. F., Chang, C. H., Yang, L. Y., Hsieh, P. H., Shih, H. N., Ueng, S. W. N., & Chang, Y. (2019). Synovial fluid interleukin-16, interleukin-18, and CRELD2 as novel biomarkers of prosthetic joint infections. Bone & Joint Research, 8(4), 179-188.

Yu, N., Wang, X., Bao, H., & Liu, Z. (2019). Identification and functional study of three nAChR regulators, ubiquilin‐1, PICK 1, and CRELD 2, in Locusta migratoria manilensis dorsal unpaired median neurons. Journal of Neurochemistry, 149(3), 331-345.

Oh-Hashi, K., Fujimura, K., Norisada, J., & Hirata, Y. (2018). Expression analysis and functional characterization of the mouse cysteine-rich with EGF-like domains 2. Scientific reports, 8(1), 1-11.

Kim, Y., Park, S. J., Manson, S. R., Molina, C. A., Kidd, K., Thiessen-Philbrook, H., ... & Chen, Y. M. (2017). Elevated urinary CRELD2 is associated with endoplasmic reticulum stress–mediated kidney disease. JCI insight, 2(23).

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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