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Rat Anti-CRHBP Recombinant Antibody (356803) (CBMAB-C5568-LY)

This product is antibody recognizes CRHBP. The antibody 356803 immunoassay techniques such as: WB.
See all CRHBP antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
356803
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse CRHBP, Tyr25-Leu322, Accession # Q60571
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Corticotropin Releasing Hormone Binding Protein
Introduction
CRHBP (Corticotropin Releasing Hormone Binding Protein) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Presynaptic function of Kainate receptors. Gene Ontology (GO) annotations related to this gene include peptide binding and corticotropin-releasing hormone binding.
Entrez Gene ID
UniProt ID
Function
Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
Biological Process
Behavioral response to ethanol Source: UniProtKB
Cellular response to calcium ion Source: UniProtKB
Cellular response to cAMP Source: UniProtKB
Cellular response to cocaine Source: UniProtKB
Cellular response to drug Source: UniProtKB
Cellular response to estradiol stimulus Source: UniProtKB
Cellular response to estrogen stimulus Source: UniProtKB
Cellular response to gonadotropin-releasing hormone Source: UniProtKB
Cellular response to potassium ion Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Female pregnancy Source: UniProtKB
Hormone-mediated signaling pathway Source: UniProtKB
Inflammatory response Source: UniProtKB
Learning or memory Source: UniProtKB
Negative regulation of corticotropin-releasing hormone receptor activity Source: UniProtKB
Negative regulation of corticotropin secretion Source: UniProtKB
Regulated exocytosis Source: UniProtKB
Regulation of cellular response to stress Source: UniProtKB
Regulation of corticotropin secretion Source: UniProtKB
Regulation of NMDA receptor activity Source: UniProtKB
Signal transduction Source: UniProtKB
Synaptic transmission, dopaminergic Source: UniProtKB
Cellular Location
Secreted

Adachi, N., Suzuki, S., Matsuoka, H., Fushimi, S., Ono, J., Ohta, K. I., ... & Koshimizu, H. (2018). Corticotropin‐releasing hormone‐binding protein is up‐regulated by brain‐derived neurotrophic factor and is secreted in an activity‐dependent manner in rat cerebral cortical neurons. Journal of neurochemistry, 146(1), 99-110.

Fabbri, C., Lewis, C. M., Perlis, R. H., & Uher, R. (2018). No Association Between Antidepressant Efficacy and rs28365143 in Corticotropin-Releasing Hormone Binding Protein in a Large Meta-Analysis. American Journal of Psychiatry, 175(6), 575-576.

Xia, H. B., Wang, H. J., Fu, L. Q., Wang, S. B., Li, L., Ru, G. Q., ... & Huang, D. S. (2018). Decreased CRHBP expression is predictive of poor prognosis in patients with hepatocellular carcinoma. Oncology Letters, 16(3), 3681-3689.

Haass-Koffler, C. L. (2018). The corticotropin releasing factor binding protein: A strange case of Dr. Jekyll and Mr. Hyde in the stress system?. Alcohol, 72, 3-8.

O’Connell, C. P., Goldstein-Piekarski, A. N., Nemeroff, C. B., Schatzberg, A. F., Debattista, C., Carrillo-Roa, T., ... & Williams, L. M. (2018). Antidepressant outcomes predicted by genetic variation in corticotropin-releasing hormone binding protein. American Journal of Psychiatry, 175(3), 251-261.

Kalin, N. H. (2018). Corticotropin-Releasing Hormone Binding Protein: Stress, Psychopathology, and Antidepressant Treatment Response. American Journal of Psychiatry, 175(3), 204-206.

Ketchesin, K. D., Stinnett, G. S., & Seasholtz, A. F. (2017). Corticotropin-releasing hormone-binding protein and stress: from invertebrates to humans. Stress, 20(5), 449-464.

Su, F., Xia, Y., Huang, M., Zhang, L., & Chen, L. (2017). Up-regulation of corticotropin releasing hormone is associated with the downregulation of corticotropin releasing hormone binding protein and up-regulation of IL-33 and IL-8 expression in psoriasis. Tropical Journal of Pharmaceutical Research, 16(11), 2595-2600.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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