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Mouse Anti-CRIM1 Recombinant Antibody (CBFYC-2206) (CBMAB-C2276-FY)

This product is mouse antibody that recognizes CRIM1. The antibody CBFYC-2206 can be used for immunoassay techniques such as: WB.
See all CRIM1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-2206
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Recombinant protein corresponding to human CRIM1
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
cysteine rich transmembrane BMP regulator 1 (chordin-like)
Introduction
CRIM1 (Cysteine Rich Transmembrane BMP Regulator 1) is a Protein Coding gene. Diseases associated with CRIM1 include Macrophthalmia, Colobomatous, With Microcornea. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity and enzyme inhibitor activity. An important paralog of this gene is KCP.
Entrez Gene ID
51232
UniProt ID
Q9NZV1
Alternative Names
Cysteine Rich Transmembrane BMP Regulator 1; Cysteine Rich Transmembrane BMP Regulator 1 (Chordin-Like); Cysteine-Rich Repeat-Containing Protein S52; CRIM-1; S52; Cysteine-Rich Motor Neuron 1 Protein; Cysteine-Rich Motor Neuron 1
Function
May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.
Biological Process
Negative regulation of BMP signaling pathway Source: ARUK-UCL
Negative regulation of osteoblast differentiation Source: ARUK-UCL
Nervous system development Source: ProtInc
Cellular Location
Processed cysteine-rich motor neuron 1 protein: Secreted; Cell membrane
Topology
Extracellular: 35-939
Helical: 940-960
Cytoplasmic: 961-1036
PTM
N-glycosylated.

Yang, D., Liu, A., Zhang, Y., Nan, S., Yin, R., Lei, Q., ... & Ding, Y. (2021). Essential role of crim1 on endometrial receptivity in goat. International journal of molecular sciences, 22(10), 5323.

Du, Y., Liu, X., Zhang, S., Chen, S., Guan, X., Li, Q., ... & Zhao, Y. (2021). CircCRIM1 promotes ovarian cancer progression by working as ceRNAs of CRIM1 and targeting miR-383-5p/ZEB2 axis. Reproductive Biology and Endocrinology, 19(1), 1-12.

Park, Y., Kim, H., Seo, H., Choi, J. Y., Ma, Y., Yun, S., ... & Kim, J. H. (2020). Homozygote CRIM1 variant is associated with thiopurine-induced neutropenia in leukemic patients with both wildtype NUDT15 and TPMT. Journal of translational medicine, 18(1), 1-13.

Furuichi, T., Tsukamoto, M., Saito, M., Sato, Y., Oiji, N., Yagami, K., ... & Tomii, K. (2019). Crim1C140S mutant mice reveal the importance of cysteine 140 in the internal region 1 of CRIM1 for its physiological functions. Mammalian Genome, 30(11), 329-338.

Yang, L., He, J., Xia, G., Yang, J., Tang, Q., Yang, Y., & Deng, J. (2019). Crim1 suppresses left ventricular hypertrophy Corrigendum in/10.3892/br. 2019.1241. Biomedical Reports, 10(6), 343-350.

Tam, O. H., Pennisi, D., Wilkinson, L., Little, M. H., Wazin, F., Wan, V. L., & Lovicu, F. J. (2018). Crim1 is required for maintenance of the ocular lens epithelium. Experimental eye research, 170, 58-66.

Iyer, S. (2017). Analysis of the Role of Crim1 in Heart Development.

Iyer, S., Chhabra, Y., Harvey, T. J., Wang, R., Chiu, H. S., Smith, A. G., ... & Piper, M. (2017). CRIM1 is necessary for coronary vascular endothelial cell development and homeostasis. Journal of molecular histology, 48(1), 53-61.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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