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Mouse Anti-CRLF1 Recombinant Antibody (4F4) (CBMAB-C6934-LY)

This product is antibody recognizes CRLF1. The antibody 4F4 immunoassay techniques such as: ELISA, IP, RNAi, WB.
See all CRLF1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4F4
Antibody Isotype
IgG2a, κ
Application
ELISA, IP, RNAi, WB

Basic Information

Immunogen
CRLF1 (NP_004741, 135 a.a. ~ 230 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: PEKPVNISCW SKNMKDLTCR WTPGAHGETF LHTNYSLKYK LRWYGQDNTC EEYHTVGPHS CHIPKDLALF TPYEIWVEAT NRLGSARSDV LTLDIL
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
cytokine receptor-like factor 1
Introduction
CRLF1 (Cytokine Receptor Like Factor 1) is a Protein Coding gene. Diseases associated with CRLF1 include Cold-Induced Sweating Syndrome 1 and Cold-Induced Sweating Syndrome. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and cytokine activity.
An important paralog of this gene is PRLR.
Entrez Gene ID
9244
UniProt ID
O75462
Alternative Names
Cytokine Receptor Like Factor 1; Cytokine-Like Factor 1; Zcytor5; CLF-1; Cytokine Receptor-Like Factor 1; Cytokine Type 1 Receptor CRLP-1; Cold-Induced Sweating Syndrome;
Function
In complex with CLCF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). May also play a regulatory role in the immune system.
Biological Process
Cytokine-mediated signaling pathway Source: GO_Central
Interleukin-27-mediated signaling pathway Source: Reactome
Negative regulation of motor neuron apoptotic process Source: Ensembl
Negative regulation of neuron apoptotic process Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
Ureteric bud development Source: Ensembl
Cellular Location
Secreted
Involvement in disease
Crisponi/Cold-induced sweating syndrome 1 (CISS1):
An autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Patients manifest, in the neonatal period, orofacial weakness with impaired sucking and swallowing, resulting in poor feeding. Affected infants show a tendency to startle, with contractions of the facial muscles in response to tactile stimuli or during crying, trismus, abundant salivation, and opisthotonus. These features are referred to as Crisponi syndrome and can result in early death in infancy. Patients who survive into childhood have hyperhidrosis, mainly of the upper body, in response to cold temperatures, and sweat very little with heat. Additional abnormalities include a high-arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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