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Rabbit Anti-CRMP1 Recombinant Antibody (EP14521) (CBMAB-1445-CN)

This product is a rabbit antibody that recognizes CRMP1 of human. The antibody EP14521 can be used for immunoassay techniques such as: FC, IF, IHC-P, IP, WB.
See all CRMP1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EP14521
Antibody Isotype
IgG
Application
FC, IF, IHC-P, IP, WB

Basic Information

Immunogen
Synthetic peptide within Human CRMP1 aa. 500 to the C-terminus.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
59% PBS, 40% Glycerol, 0.05% BSA
Preservative
0.01% Sodium azide
Concentration
0.108 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
collapsin response mediator protein 1
Introduction
This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. The protein plays a role in axon guidance, invasive growth and cell migration. This protein may participate in cytokinesis.
Entrez Gene ID
Human1400
Mouse12933
Rat25415
UniProt ID
HumanQ14194
MouseP97427
RatQ62950
Alternative Names
DRP1; DRP-1; CRMP-1; DPYSL1; ULIP-3
Function
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863).

Plays a role in axon guidance (PubMed:25358863).

During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863).

Involved in invasive growth and cell migration (PubMed:11562390).

May participate in cytokinesis (PubMed:19799413).
Biological Process
Axon guidance Source: InterPro
Microtubule cytoskeleton organization Source: InterPro
Negative regulation of actin filament binding Source: WormBase
Negative regulation of neuron projection development Source: WormBase
Nervous system development Source: ProtInc
Nucleobase-containing compound metabolic process Source: ProtInc
Cellular Location
Centrosome; Spindle; Cytoskeleton; Cytoplasm; Growth cone; Perikaryon. Associated with centrosomes and the mitotic spindle during metaphase (PubMed:11562390). Colocalizes with FLNA and tubulin in the central region of DRG neuron growth cone (By similarity). Following SEMA3A stimulation of DRG neurons, colocalizes with F-actin (By similarity).
PTM
Phosphorylation at Ser-522 enhances CRMP1-mediated alteration of FLNA ternary structure and FLNA dissociation from F-actin.

Li, J., Liu, C., & Zhao, B. (2022). Collapsin Response Mediator Protein 1 (CRMP1) Is Required for High-Frequency Hearing. The American Journal of Pathology.

Kawashima, T., Jitsuki‐Takahashi, A., Takizawa, K., Jitsuki, S., Takahashi, T., Ohshima, T., ... & Nakamura, F. (2021). Phosphorylation of Collapsin Response Mediator Protein 1 (CRMP1) at Tyrosine 504 residue regulates Semaphorin 3A‐induced cortical dendritic growth. Journal of Neurochemistry, 157(4), 1207-1221.

Chua, J. Y., Ng, S. J., Yagensky, O., Wanker, E. E., & Chua, J. J. E. (2021). FEZ1 forms complexes with CRMP1 and DCC to regulate axon and dendrite development. Eneuro, 8(2).

Panchal, I. I., Rajput, R., & Patel, A. D. (2020). Design, synthesis and pharmacological evalution of 1, 3, 4-oxadiazole derivatives as collapsin response mediator protein 1 (CRMP 1) inhibitors. Current drug discovery technologies, 17(1), 57-67.

Yamazaki, Y., Nagai, J., Akinaga, S., Koga, Y., Hasegawa, M., Takahashi, M., ... & Ohshima, T. (2020). Phosphorylation of CRMP2 is required for migration and positioning of Purkinje cells: Redundant roles of CRMP1 and CRMP4. Brain Research, 1736, 146762.

Huang, L., Li, Y., Wang, C., Li, N., Hou, Y., Chang, R., ... & Qiao, C. (2019). Overexpression of collapsin response mediator protein 1 inhibits human trophoblast cells proliferation, migration, and invasion. Reproductive Sciences, 26(7), 954-960.

Miyazaki, T., Baba, T. T., Mori, M., & Komori, T. (2018). Collapsin Response Mediator Protein 1, a Novel Marker Protein for Differentiated Odontoblasts. Acta Histochemica et Cytochemica, 51(6), 185-190.

Cai, G., Wu, D., Wang, Z., Xu, Z., Wong, K. B., Ng, C. F., ... & Yu, S. (2017). Collapsin response mediator protein-1 (CRMP1) acts as an invasion and metastasis suppressor of prostate cancer via its suppression of epithelial–mesenchymal transition and remodeling of actin cytoskeleton organization. Oncogene, 36(4), 546-558.

Ren, L., Li, F., Di, M., Fu, Y., Hui, Y., Xiao, G., ... & Du, X. (2017). MicroRNA-187 regulates gastric cancer progression by targeting the tumor suppressor CRMP1. Biochemical and biophysical research communications, 482(4), 597-603.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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