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Mouse Anti-CRNN Recombinant Antibody (CBXC-1735) (CBMAB-C5851-CQ)

This product is a mouse antibody that recognizes CRNN. The antibody CBXC-1735 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all CRNN antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-1735
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cornulin
Introduction
CRNN (Cornulin) is a Protein Coding gene. Diseases associated with CRNN include Oral Squamous Cell Carcinoma. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is FLG2.
Entrez Gene ID
49860
UniProt ID
Q9UBG3
Alternative Names
Cornulin; 53 KDa Squamous Epithelial-Induced Stress Protein; Squamous Epithelial Heat Shock Protein 53; 53 KDa Putative Calcium-Binding Protein; 58 KDa Heat Shock Protein; Tumor-Related Protein;
Function
Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1 (PubMed:30009832).

Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways (PubMed:30009832).
Biological Process
Cell-cell adhesion Source: UniProtKB
Cellular response to cytokine stimulus Source: UniProtKB
Positive regulation of cell cycle G1/S phase transition Source: UniProtKB
Positive regulation of keratinocyte proliferation Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Regulation of gene expression Source: UniProtKB
Regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
Response to heat Source: UniProtKB
Cellular Location
Cytoplasm. Does not colocalize with TGM1.
Involvement in disease
Esophageal cancer (ESCR):
A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.

Saleem, S., Aleem, I., Atiq, A., Tariq, S., Babar, A., Bakar, M. A., ... & Sutton, C. (2021). Expression of cornulin in tongue squamous cell carcinoma. ecancermedicalscience, 15.

Selvaraj, J., Jh, S. F., Sivabalan, V., Rekha, U. V., Ponnulakshmi, R., Vishnupriya, V., ... & Vijayalakshmi, P. (2021). Molecular modeling of cornulin (CRNN) for docking with phytocompounds from Justicia adhatoda L. Bioinformation, 17(1), 200-205.

Kaur, R., Chauhan, A., Bhat, S. A., Chatterjee, D., Ghoshal, S., & Pal, A. (2021). Gene of the month: Cornulin. Journal of clinical pathology.

Shehata, W. A., Hammam, M. A., Ayad, A., & Holah, N. S. (2021). Immunohistochemical expression of cornulin in lesional and perilesional skin of plaque psoriasis. Journal of cosmetic dermatology.

Li, C., Xiao, L., Jia, J., Li, F., Wang, X., Duan, Q., ... & Zheng, Y. (2019). Cornulin is induced in psoriasis lesions and promotes keratinocyte proliferation via phosphoinositide 3-kinase/Akt pathways. Journal of Investigative Dermatology, 139(1), 71-80.

Sundkvist, A., Myte, R., Bodén, S., Enroth, S., Gyllensten, U., Harlid, S., & van Guelpen, B. (2018). Targeted plasma proteomics identifies a novel, robust association between cornulin and Swedish moist snuff. Scientific reports, 8(1), 1-10.

Trzeciak, M., Sakowicz-Burkiewicz, M., Wesserling, M., Gleń, J., Dobaczewska, D., Bandurski, T., ... & Pawelczyk, T. (2017). Altered expression of genes encoding cornulin and repetin in atopic dermatitis. International archives of allergy and immunology, 172(1), 11-19.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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