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Mouse Anti-CRP (AA 20-222) Recombinant Antibody (CBFYC-2223) (CBMAB-C2293-FY)

This product is mouse antibody that recognizes CRP. The antibody CBFYC-2223 can be used for immunoassay techniques such as: ELISA, ICC, IHC, WB.
See all CRP antibodies

Summary

Host Animal
Mouse
Specificity
Pig
Clone
CBFYC-2223
Antibody Isotype
IgG1, k
Application
ELISA, ICC, IHC, WB

Basic Information

Immunogen
Recombinant protein corresponding to aa20-222 with an N-Terminal His-Tag from porcine CRP, expressed in E. coli
Specificity
Pig
Antibody Isotype
IgG1, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 20-222

Target

Full Name
C-Reactive Protein
Introduction
CRP (C-Reactive Protein) is a Protein Coding gene. Diseases associated with CRP include Acute Pancreatitis and Appendicitis. Among its related pathways are Creation of C4 and C2 activators and Overview of nanoparticle effects. Gene Ontology (GO) annotations related to this gene include calcium ion binding and cholesterol binding. An important paralog of this gene is APCS.
Entrez Gene ID
UniProt ID
Alternative Names
C-reactive protein
Function
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
Biological Process
Acute-phase response Source: BHF-UCL
Complement activation, classical pathway Source: GO_Central
Defense response to Gram-positive bacterium Source: BHF-UCL
Inflammatory response Source: ProtInc
Innate immune response Source: GO_Central
Negative regulation by host of viral process Source: GO_Central
Negative regulation of lipid storage Source: BHF-UCL
Negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
Negative regulation of mononuclear cell proliferation Source: CACAO
Opsonization Source: BHF-UCL
Positive regulation of gene expression Source: AgBase
Positive regulation of superoxide anion generation Source: AgBase
Regulation of interleukin-8 production Source: UniProtKB
Vasoconstriction Source: GO_Central
Cellular Location
Secreted

Luo, X., Zhou, W., Yan, X., Guo, T., Wang, B., Xia, H., ... & Yang, W. (2020). Prognostic value of C-reactive protein in patients with coronavirus 2019. Clinical Infectious Diseases, 71(16), 2174-2179.

Wang, G., Wu, C., Zhang, Q., Wu, F., Yu, B., Lv, J., ... & Zhong, Y. (2020, May). C-reactive protein level may predict the risk of COVID-19 aggravation. In Open forum infectious diseases (Vol. 7, No. 5, p. ofaa153). US: Oxford University Press.

Pathak, A., & Agrawal, A. (2019). Evolution of C-reactive protein. Frontiers in immunology, 10, 943.

Sproston, N. R., & Ashworth, J. J. (2018). Role of C-reactive protein at sites of inflammation and infection. Frontiers in immunology, 9, 754.

Ticinesi, A., Lauretani, F., Nouvenne, A., Porro, E., Fanelli, G., Maggio, M., & Meschi, T. (2017). C-reactive protein (CRP) measurement in geriatric patients hospitalized for acute infection. European Journal of Internal Medicine, 37, 7-12.

Nehring, S. M., & Patel, B. C. (2017). C reactive protein (CRP).

Moutachakkir, M., Baraou, A., Boukhira, A., & Chellak, S. (2017, April). Immunoanalytical characteristics of C-reactive protein and high sensitivity C-reactive protein. In Annales de biologie clinique (Vol. 75, No. 2, pp. 225-229).

Köhler-Forsberg, O., Buttenschøn, H. N., Tansey, K. E., Maier, W., Hauser, J., Dernovsek, M. Z., ... & Mors, O. (2017). Association between C-reactive protein (CRP) with depression symptom severity and specific depressive symptoms in major depression. Brain, behavior, and immunity, 62, 344-350.

Stirling, A. D., Moran, N. R., Kelly, M. E., Ridgway, P. F., & Conlon, K. C. (2017). The predictive value of C-reactive protein (CRP) in acute pancreatitis–is interval change in CRP an additional indicator of severity?. Hpb, 19(10), 874-880.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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