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Rat Anti-CRTAM Recombinant Antibody (11-5/CRTAM) (CBMAB-C0211-LY)

This product is antibody recognizes CRTAM. The antibody 11-5/CRTAM immunoassay techniques such as: FC.
See all CRTAM antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
11-5/CRTAM
Antibody Isotype
IgG2a, κ
Application
FC

Basic Information

Immunogen
CRTAM extracellular region-human IgG Fc fusion protein
Specificity
Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cytotoxic And Regulatory T Cell Molecule
Introduction
CRTAM (Cytotoxic And Regulatory T Cell Molecule) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include receptor binding. An important paralog of this gene is CADM1.
Entrez Gene ID
54698
UniProt ID
Q149L7
Function
Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets (By similarity).

Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952).

Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation (By similarity).

Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity (By similarity).

Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production (By similarity).

By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node (By similarity).

Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity).

Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity).
Biological Process
Adaptive immune response Source: UniProtKB-KW
Cell recognition Source: HGNC-UCL
Detection of stimulus Source: HGNC-UCL
Detection of tumor cell Source: HGNC-UCL
Establishment of T cell polarity Source: UniProtKB
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Lymphocyte migration into lymphoid organs Source: UniProtKB
Negative regulation of activated T cell proliferation Source: UniProtKB
Positive regulation of cytokine production Source: HGNC-UCL
Positive regulation of interferon-gamma production Source: UniProtKB
Positive regulation of natural killer cell mediated cytotoxicity Source: HGNC-UCL
Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: HGNC-UCL
Regulation of CD8-positive, alpha-beta T cell activation Source: UniProtKB
Regulation of immune response Source: Reactome
Regulation of T cell activation Source: UniProtKB
Regulation of T cell differentiation Source: UniProtKB
Cellular Location
Cell membrane. In a subset of CD4+ T-cells, colocalizes with SCRIB at the immunological synapse during the late phase of T-cell activation.
Topology
Extracellular: 18-287
Helical: 288-308
Cytoplasmic: 309-393
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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