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Mouse Anti-CSF1 Recombinant Antibody (CBXC-2007) (CBMAB-C4225-CQ)

This product is a mouse antibody that recognizes CSF1. The antibody CBXC-2007 can be used for immunoassay techniques such as: WB.
See all CSF1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-2007
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Recombinant protein corresponding to amino acids 223-496 of human CSF1(NP_000748) produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Colony Stimulating Factor 1
Introduction
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
UniProt ID
Alternative Names
Colony Stimulating Factor 1; Colony Stimulating Factor 1 (Macrophage); Macrophage Colony Stimulating Factor 1; Lanimostim; CSF-1; MCSF; Macrophage Colony-Stimulating Factor 1; M-CSF;
Function
Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
Biological Process
Branching involved in mammary gland duct morphogenesis Source: Ensembl
Cellular protein metabolic process Source: Reactome
Cytokine-mediated signaling pathway Source: Reactome
Developmental process involved in reproduction Source: BHF-UCL
Homeostasis of number of cells within a tissue Source: Ensembl
Inflammatory response Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
Macrophage colony-stimulating factor signaling pathway Source: Ensembl
Macrophage differentiation Source: UniProtKB
Mammary duct terminal end bud growth Source: Ensembl
Mammary gland fat development Source: Ensembl
Microglial cell proliferation Source: Ensembl
Monocyte activation Source: BHF-UCL
Negative regulation of neuron death Source: ARUK-UCL
Osteoclast differentiation Source: BHF-UCL
Osteoclast proliferation Source: Ensembl
Positive regulation of cell-matrix adhesion Source: BHF-UCL
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of cell population proliferation Source: MGI
Positive regulation of cellular protein metabolic process Source: BHF-UCL
Positive regulation of gene expression Source: BHF-UCL
Positive regulation of macrophage chemotaxis Source: BHF-UCL
Positive regulation of macrophage colony-stimulating factor signaling pathway Source: BHF-UCL
Positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
Positive regulation of macrophage differentiation Source: BHF-UCL
Positive regulation of microglial cell migration Source: BHF-UCL
Positive regulation of monocyte differentiation Source: BHF-UCL
Positive regulation of mononuclear cell proliferation Source: BHF-UCL
Positive regulation of multicellular organism growth Source: Ensembl
Positive regulation of odontogenesis of dentin-containing tooth Source: Ensembl
Positive regulation of osteoclast differentiation Source: BHF-UCL
Positive regulation of protein kinase activity Source: BHF-UCL
Positive regulation of Ras protein signal transduction Source: Ensembl
Post-translational protein modification Source: Reactome
Regulation of macrophage derived foam cell differentiation Source: BHF-UCL
Regulation of ossification Source: Ensembl
Response to ischemia Source: ARUK-UCL
Transmembrane receptor protein tyrosine kinase signaling pathway Source: BHF-UCL
Cellular Location
Cell membrane
Processed macrophage colony-stimulating factor 1: Extracellular space
Involvement in disease
Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers.
Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection.
Topology
Lumenal: 33-496
Helical: 497-517
Cytoplasmic: 518-554
PTM
N- and O-glycosylated. Glycosylation and proteolytic cleavage yield different soluble forms. One high molecular weight soluble form is a proteoglycan containing chondroitin sulfate. O-glycosylated with core 1 or possibly core 8 glycans. Isoform 1 is N- and O-glycosylated. Isoform 3 is only N-glycosylated.

Yu, X., Basbaum, A., & Guan, Z. (2021). Contribution of colony-stimulating factor 1 to neuropathic pain. Pain reports, 6(1).

Kaur, S., Sehgal, A., Wu, A. C., Millard, S. M., Batoon, L., Sandrock, C. J., ... & Pettit, A. R. (2021). Stable colony-stimulating factor 1 fusion protein treatment increases hematopoietic stem cell pool and enhances their mobilisation in mice. Journal of Hematology & Oncology, 14(1), 1-19.

Pognan, F., Couttet, P., Demin, I., Jaitner, B., Pang, Y., Roubenoff, R., ... & Schramm, U. (2019). Colony-stimulating factor-1 antibody lacnotuzumab in a phase 1 healthy volunteer study and mechanistic investigation of safety outcomes. Journal of Pharmacology and Experimental Therapeutics, 369(3), 428-442.

Zhu, Y., Yang, J., Xu, D., Gao, X. M., Zhang, Z., Hsu, J. L., ... & Qin, L. X. (2019). Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade. Gut, 68(9), 1653-1666.

Okugawa, Y., Toiyama, Y., Ichikawa, T., Kawamura, M., Yasuda, H., Fujikawa, H., ... & Kusunoki, M. (2018). Colony-stimulating factor-1 and colony-stimulating factor-1 receptor co-expression is associated with disease progression in gastric cancer. International journal of oncology, 53(2), 737-749.

Kumari, A., Silakari, O., & Singh, R. K. (2018). Recent advances in colony stimulating factor-1 receptor/c-FMS as an emerging target for various therapeutic implications. Biomedicine & Pharmacotherapy, 103, 662-679.

Wohleb, E. S., Terwilliger, R., Duman, C. H., & Duman, R. S. (2018). Stress-induced neuronal colony stimulating factor 1 provokes microglia-mediated neuronal remodeling and depressive-like behavior. Biological psychiatry, 83(1), 38-49.

Cannarile, M. A., Weisser, M., Jacob, W., Jegg, A. M., Ries, C. H., & Rüttinger, D. (2017). Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy. Journal for immunotherapy of cancer, 5(1), 1-13.

Papadopoulos, K. P., Gluck, L., Martin, L. P., Olszanski, A. J., Tolcher, A. W., Ngarmchamnanrith, G., ... & Stephenson, J. (2017). First-in-human study of AMG 820, a monoclonal anti-colony-stimulating factor 1 receptor antibody, in patients with advanced solid tumors. Clinical Cancer Research, 23(19), 5703-5710.

Walker, D. G., Tang, T. M., & Lue, L. F. (2017). Studies on colony stimulating factor receptor-1 and ligands colony stimulating factor-1 and interleukin-34 in Alzheimer's disease brains and human microglia. Frontiers in aging neuroscience, 9, 244.

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For research use only. Not intended for any clinical use.

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