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Mouse Anti-CSF2 Recombinant Antibody (CBFYC-2280) (CBMAB-C2352-FY)

This product is mouse antibody that recognizes CSF2. The antibody CBFYC-2280 can be used for immunoassay techniques such as: ELISA, IHC, WB.
See all CSF2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-2280
Antibody Isotype
IgG1
Application
ELISA, IHC, WB

Basic Information

Immunogen
Recombinant human GM-CSF produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Colony Stimulating Factor 2
Introduction
CSF2 (Colony Stimulating Factor 2) is a Protein Coding gene. Diseases associated with CSF2 include Mucositis and Cyclic Neutropenia. Among its related pathways are RET signaling and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and granulocyte macrophage colony-stimulating factor receptor binding.
Entrez Gene ID
UniProt ID
Alternative Names
Colony Stimulating Factor 2; Sargramostim; Molgramostin; Colony Stimulating Factor 2 (Granulocyte-Macrophage); GMCSF; CSF
Function
Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
Biological Process
Cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: CAFA
Cellular response to lipopolysaccharide Source: Ensembl
Cytokine-mediated signaling pathway Source: Reactome
Dendritic cell differentiation Source: DFLAT
Embryonic placenta development Source: Ensembl
Epithelial fluid transport Source: Ensembl
Histamine secretion Source: Ensembl
Immune response Source: InterPro
Macrophage activation Source: Ensembl
Macrophage differentiation Source: ARUK-UCL
MAPK cascade Source: Reactome
Monocyte differentiation Source: Ensembl
Myeloid cell differentiation Source: GO_Central
Myeloid dendritic cell differentiation Source: UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
Neutrophil differentiation Source: Ensembl
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of gene expression Source: BHF-UCL
Positive regulation of interleukin-23 production Source: BHF-UCL
Positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
Positive regulation of podosome assembly Source: BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
Regulation of circadian sleep/wake cycle, sleep Source: Ensembl
Regulation of myeloid cell differentiation Source: Reactome
Response to fluid shear stress Source: Ensembl
Response to silicon dioxide Source: Ensembl
Cellular Location
Secreted

Xiao, Y., Uh, K., Negrón-Pérez, V. M., Haines, H., Lee, K., & Hansen, P. J. (2021). Regulation of gene expression in the bovine blastocyst by colony-stimulating factor 2 is disrupted by CRISPR/Cas9-mediated deletion of CSF2RA. Biology of Reproduction, 104(5), 995-1007.

Estrada-Cortés, E., Jannaman, E. A., Block, J., Amaral, T. F., & Hansen, P. J. (2021). Programming of postnatal phenotype caused by exposure of cultured embryos from Brahman cattle to colony-stimulating factor 2 and serum. Journal of Animal Science, 99(8), skab180.

Sinkey, R. G., Guzeloglu-Kayisli, O., Arlier, S., Guo, X., Semerci, N., Moore, R., ... & Lockwood, C. J. (2020). Thrombin-induced decidual colony-stimulating factor-2 promotes abruption-related preterm birth by weakening fetal membranes. The American journal of pathology, 190(2), 388-399.

Sosa, F., Block, J., Xiao, Y., & Hansen, P. J. (2020). Determinants of survival of the bovine blastocyst to cryopreservation stress: treatment with colony stimulating factor 2 during the morula-to-blastocyst transition and embryo sex. CABI agriculture and bioscience, 1(1), 1-10.

Sielska, M., Przanowski, P., Pasierbińska, M., Wojnicki, K., Poleszak, K., Wojtas, B., ... & Kaminska, B. (2020). Tumour-derived CSF2/granulocyte macrophage colony stimulating factor controls myeloid cell accumulation and progression of gliomas. British journal of cancer, 123(3), 438-448.

Sharkey, D. J., Glynn, D. J., Schjenken, J. E., Tremellen, K. P., & Robertson, S. A. (2018). Interferon-gamma inhibits seminal plasma induction of colony-stimulating factor 2 in mouse and human reproductive tract epithelial cells. Biology of reproduction, 99(3), 514-526.

Tríbulo, P., Bernal Ballesteros, B. H., Ruiz, A., Tríbulo, A., Tríbulo, R. J., Tríbulo, H. E., ... & Hansen, P. J. (2017). Consequences of exposure of embryos produced in vitro in a serum-containing medium to dickkopf-related protein 1 and colony stimulating factor 2 on blastocyst yield, pregnancy rate, and birth weight. Journal of animal science, 95(10), 4407-4412.

Siqueira, L. G., Tribulo, P., Chen, Z., Denicol, A. C., Ortega, M. S., Negrón-Pérez, V. M., ... & Hansen, P. J. (2017). Colony-stimulating factor 2 acts from days 5 to 7 of development to modify programming of the bovine conceptus at day 86 of gestation. Biology of Reproduction, 96(4), 743-757.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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