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Rat Anti-CSF2RB Recombinant Antibody (RM0112-42A7) (CBMAB-C11231-LY)

The product is antibody recognizes CSF2RB. The antibody RM0112-42A7 immunoassay techniques such as: WB.
See all CSF2RB antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
RM0112-42A7
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Mouse recombinant protein of the extracellular domain of IL-3 R Beta
Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Colony Stimulating Factor 2 Receptor Beta Common Subunit
Introduction
CSF2RB (Colony Stimulating Factor 2 Receptor Beta Common Subunit) is a Protein Coding gene. Diseases associated with CSF2RB include Surfactant Metabolism Dysfunction, Pulmonary, 5 and Hereditary Pulmonary Alveolar Proteinosis. Among its related pathways are RET signaling and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include receptor activity and interleukin-3 receptor activity.
Entrez Gene ID
12983
UniProt ID
P26955
Function
High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.
Biological Process
Cellular protein metabolic process Source: Reactome
Cellular response to interleukin-3 Source: GOC
Cytokine-mediated signaling pathway Source: Reactome
Interleukin-3-mediated signaling pathway Source: GOC
Interleukin-5-mediated signaling pathway Source: GOC
MAPK cascade Source: Reactome
Respiratory gaseous exchange by respiratory system Source: ProtInc
Response to lipopolysaccharide Source: Ensembl
Signal transduction Source: UniProtKB
Cellular Location
Membrane
Involvement in disease
Pulmonary surfactant metabolism dysfunction 5 (SMDP5):
A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
Topology
Extracellular: 17-443
Helical: 444-460
Cytoplasmic: 461-897
PTM
May be phosphorylated by LYN.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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