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Mouse Anti-CSF3R Recombinant Antibody (3H137) (CBMAB-G1474-LY)

This product is antibody recognizes CSF3R. The antibody 3H137 immunoassay techniques such as: ELISA, WB.
See all CSF3R antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3H137
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
Purified recombinant MBP-GCSFR fusion protein
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
40% glycerol
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Colony Stimulating Factor 3 Receptor
Entrez Gene ID
1441
UniProt ID
Q99062
Alternative Names
Colony Stimulating Factor 3 Receptor; Colony Stimulating Factor 3 Receptor (Granulocyte); G-CSF Receptor; CD114 Antigen; G-CSF-R; GCSFR; Granulocyte Colony-Stimulating Factor Receptor; CD114; SCN7;
Function
Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface.
Biological Process
Amelogenesis Source: Ensembl
Cell adhesion Source: UniProtKB-KW
Cytokine-mediated signaling pathway Source: GO_Central
Defense response Source: ProtInc
Neutrophil chemotaxis Source: Ensembl
Regulation of myeloid cell differentiation Source: Ensembl
Signal transduction Source: ProtInc
Cellular Location
Isoform 2: Secreted; Cell membrane
Involvement in disease
Hereditary neutrophilia (NEUTROPHILIA):
A form of lifelong, persistent neutrophilia, a condition characterized by an increase in the number of neutrophils in the blood.
Neutropenia, severe congenital 7, autosomal recessive (SCN7):
A form of severe congenital neutropenia, a disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.
Topology
Extracellular: 25-627
Helical: 628-650
Cytoplasmic: 651-836
PTM
N-glycosylated.

Chen, X., Wang, B., Pang, A., Yuan, W., Jiang, E., Chu, Y., ... & Han, M. (2021). Colony-stimulating factor 3 receptor (CSF3R) M696T mutation does not impact on clinical outcomes of a Ph+ acute lymphoblastic leukemia patient. Blood Science, 3(03), 87-92.

Kwon, A., Ibrahim, I., Le, T., Jaso, J., Weinberg, O., Fuda, F., & Chen, W. (2021). Colony-stimulating factor 3 receptor gene (CSF3R) T618I mutated chronic myelomonocytic leukemia: A proliferative subtype with a distinct mutational profile. American Journal of Clinical Pathology, 156(Supplement_1), S95-S95.

Saunders, A. S., Bender, D. E., Ray, A. L., Wu, X., & Morris, K. T. (2021). Colony-stimulating factor 3 signaling in colon and rectal cancers: Immune response and CMS classification in TCGA data. Plos one, 16(2), e0247233.

Tarlock, K., Alonzo, T., Wang, Y. C., Gerbing, R. B., Ries, R. E., Hylkema, T., ... & Meshinchi, S. (2020). Prognostic impact of CSF3R mutations in favorable risk childhood acute myeloid leukemia. Blood, 135(18), 1603-1606.

Yilmaz Karapinar, D., Akinci, B., Şahin Yaşar, A., Hekimci Özdemir, H., Önder Siviş, Z., Onay, H., & Özkinay, F. (2019). Congenital neutropenia patient with hypomorphic biallelic CSF3R mutation responding to GCSF. Journal of Pediatric Hematology/Oncology, 41(3), e190-e192.

Zhang, H., Coblentz, C., Watanabe-Smith, K., Means, S., Means, J., Maxson, J. E., & Tyner, J. W. (2018). Gain-of-function mutations in granulocyte colony–stimulating factor receptor (CSF3R) reveal distinct mechanisms of CSF3R activation. Journal of Biological Chemistry, 293(19), 7387-7396.

Qiu, Y., Zhang, Y., Hu, N., & Dong, F. (2017). A truncated granulocyte colony-stimulating factor receptor (G-CSFR) inhibits apoptosis induced by neutrophil elastase G185R mutant: implication for understanding CSF3R gene mutations in severe congenital neutropenia. Journal of Biological Chemistry, 292(8), 3496-3505.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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