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Mouse Anti-CSNK1G2 Recombinant Antibody (2E6) (CBMAB-A1929-LY)

The product is antibody recognizes CSNK1G2. The antibody 2E6 immunoassay techniques such as: WB, ELISA.
See all CSNK1G2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2E6
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
CSNK1G2 (AAH20972.1, 1 a.a. ~ 415 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
casein kinase 1, gamma 2
Entrez Gene ID
1455
UniProt ID
P78368
Alternative Names
CK1g2
Function
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.
Biological Process
Endocytosis Source: GO_Central
Peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of canonical Wnt signaling pathway Source: GO_Central
Protein autophosphorylation Source: Ensembl
Protein phosphorylation Source: ProtInc
Signal transduction Source: ProtInc
Sphingolipid biosynthetic process Source: Reactome
Wnt signaling pathway Source: GO_Central
Cellular Location
Cytoplasm; Cell cortex
PTM
Autophosphorylated (PubMed:18794808). Phosphorylated by aPKC which promotes dissociation from the cell cortex (PubMed:26481050).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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