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Mouse Anti-CSRP3 (AA 95-195) Recombinant Antibody (CBFYC-2316) (CBMAB-C2388-FY)

This product is mouse antibody that recognizes CSRP3. The antibody CBFYC-2316 can be used for immunoassay techniques such as: ELISA, WB.
See all CSRP3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-2316
Antibody Isotype
IgG2a
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 95-195

Target

Full Name
cysteine and glycine-rich protein 3 (cardiac LIM protein)
Introduction
CSRP3 (Cysteine And Glycine Rich Protein 3) is a Protein Coding gene. Diseases associated with CSRP3 include Cardiomyopathy, Familial Hypertrophic, 12 and Cardiomyopathy, Dilated, 1M. Gene Ontology (GO) annotations related to this gene include structural constituent of muscle and telethonin binding. An important paralog of this gene is CSRP2.
Entrez Gene ID
8048
UniProt ID
P50461
Alternative Names
Cysteine And Glycine Rich Protein 3; Cardiac LIM Protein; CRP3; CLP; MLP; Cysteine And Glycine-Rich Protein 3 (Cardiac LIM Protein); Cysteine And Glycine-Rich Protein 3; LIM Domain Protein, Cardiac; Cardiac LIM Domain Protein
Function
Positive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity).

Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity).

The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly: Shown to enhance CFL2-mediated F-actin depolymerization dependent on the CSRP3:CFL2 molecular ratio, and also shown to reduce the ability of CLF1 and CFL2 to enhance actin depolymerization (PubMed:19752190, PubMed:24934443).

Proposed to contribute to the maintenance of muscle cell integerity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association (PubMed:24934443).

In vitro can inhibit PKC/PRKCA activity (PubMed:27353086).

Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (By similarity).

Isoform 2:
May play a role in early sarcomere organization. Overexpression in myotubes negatively regulates myotube differentiation. By association with isoform 1 and thus changing the CSRP3 isoform 1:CFL2 stoichiometry is proposed to down-regulate CFL2-mediated F-actin depolymerization.
Biological Process
Actin cytoskeleton organization Source: GO_Central
Cardiac muscle contraction Source: BHF-UCL
Cardiac muscle hypertrophy Source: BHF-UCL
Cardiac muscle tissue development Source: BHF-UCL
Cardiac myofibril assembly Source: BHF-UCL
Cellular calcium ion homeostasis Source: BHF-UCL
Detection of muscle stretch Source: BHF-UCL
Glucose homeostasis Source: Ensembl
Inflammatory response Source: Ensembl
Insulin receptor signaling pathway Source: Ensembl
Muscle tissue development Source: GO_Central
Negative regulation of actin filament severing Source: MGI
Negative regulation of myoblast differentiation Source: MGI
Positive regulation of actin filament severing Source: MGI
Positive regulation of myoblast differentiation Source: MGI
Positive regulation of transcription by RNA polymerase II Source: MGI
Protein kinase C signaling Source: Ensembl
Protein localization to organelle Source: BHF-UCL
Regulation of protein localization to plasma membrane Source: Ensembl
Regulation of the force of heart contraction Source: BHF-UCL
Sarcomere organization Source: GO_Central
Skeletal muscle tissue development Source: ProtInc
T-tubule organization Source: Ensembl
Cellular Location
Cytoskeleton; Cytoplasm; Nucleus; Z line; Sarcomere. Nucleocytoplasmic shuttling protein. Mainly cytoplasmic. In the Z line, found associated with GLRX3 (By similarity).
Isoform 2: Z line
Involvement in disease
Cardiomyopathy, dilated 1M (CMD1M):
A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Cardiomyopathy, familial hypertrophic 12 (CMH12):
A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
PTM
Phosphorylated by PKC/PRKCA.
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For research use only. Not intended for any clinical use.

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