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Rabbit Anti-CST1 Recombinant Antibody (003) (CBMAB-C1496-LY)

This product is antibody recognizes CST1. The antibody 003 immunoassay techniques such as: ELISA(Cap).
See all CST1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
003
Antibody Isotype
IgG
Application
ELISA(Cap)

Basic Information

Immunogen
Recombinant Human Cystatin SN / CST1 Protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cystatin SN
Introduction
CST1 (Cystatin SN) is a Protein Coding gene. Diseases associated with CST1 include Dental Caries. Among its related pathways are Salivary secretion. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CST4.
Entrez Gene ID
1469
UniProt ID
P01037
Alternative Names
Cystatin SN; Salivary Cystatin-SA-1; Cystain-SA-I; Cysteine Proteinase Inhibitor, Type 2 Family; Cystatin SA-I; Cystatin-SN; Cystatin 1; Cystatin-1;
Function
Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well.
Biological Process
Detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB
Cellular Location
Secreted

Ding, J., Wang, X., Gao, J., & Song, T. (2021). Silencing of cystatin SN abrogates cancer progression and stem cell properties in papillary thyroid carcinoma. FEBS Open bio, 11(8), 2186-2197.

Fukuoka, A., Matsushita, K., Morikawa, T., Adachi, T., Yasuda, K., Kiyonari, H., ... & Yoshimoto, T. (2019). Human cystatin SN is an endogenous protease inhibitor that prevents allergic rhinitis. Journal of Allergy and Clinical Immunology, 143(3), 1153-1162.

Yan, B., Lou, H., Wang, Y., Li, Y., Meng, Y., Qi, S., ... & Zhang, L. (2019). Epithelium-derived cystatin SN enhances eosinophil activation and infiltration through IL-5 in patients with chronic rhinosinusitis with nasal polyps. Journal of Allergy and Clinical Immunology, 144(2), 455-469.

Liu, Y., & Yao, J. (2019). Research progress of cystatin SN in cancer. OncoTargets and therapy, 12, 3411.

Liu, Y., Ma, H., Wang, Y., Du, X., & Yao, J. (2019). Cystatin SN affects cell proliferation by regulating the ERα/PI3K/AKT/ERα loopback pathway in breast cancer. OncoTargets and therapy, 12, 11359.

Mueller, S. K., Nocera, A. L., Dillon, S. T., Gu, X., Wendler, O., Otu, H. H., ... & Bleier, B. S. (2019, February). Noninvasive exosomal proteomic biosignatures, including cystatin SN, peroxiredoxin‐5, and glycoprotein VI, accurately predict chronic rhinosinusitis with nasal polyps. In International Forum of Allergy & Rhinology (Vol. 9, No. 2, pp. 177-186).

Cui, Y., Sun, D., Song, R., Zhang, S., Liu, X., Wang, Y., ... & Liu, L. (2019). Upregulation of cystatin SN promotes hepatocellular carcinoma progression and predicts a poor prognosis. Journal of Cellular Physiology, 234(12), 22623-22634.

Oh, S. S., Park, S., Lee, K. W., Madhi, H., Park, S. G., Lee, H. G., ... & Dong Kim, K. (2017). Extracellular cystatin SN and cathepsin B prevent cellular senescence by inhibiting abnormal glycogen accumulation. Cell death & disease, 8(4), e2729-e2729.

Oh, B. M., Lee, S. J., Cho, H. J., Park, Y. S., Kim, J. T., Yoon, S. R., ... & Lee, H. G. (2017). Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutathione reductase activity in colorectal cancer. Cell death & disease, 8(3), e2682-e2682.

Li, T., Xiong, Q., Zou, Z., Lei, X., Jiang, Q., & Liu, D. (2017). Prognostic significance of cystatin SN associated nomograms in patients with colorectal cancer. Oncotarget, 8(70), 115153.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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