Mouse Anti-CST5 Recombinant Antibody (MM0230-4K33) (CBMAB-C11259-LY)

The product is antibody recognizes CST5. The antibody MM0230-4K33 immunoassay techniques such as: WB, Blocking/Neutralization.
See all CST5 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

MM0230-4K33

Antibody Isotype

IgG1

Application

WB, Blocking/Neutralization

Basic Information

Immunogen

Human Cystatin D

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Cystatin D

Introduction

CST5 (Cystatin D) is a Protein Coding gene. Diseases associated with CST5 include Central Corneal Ulcer. Among its related pathways are Endochondral Ossification and Salivary secretion. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CST1.

Entrez Gene ID

1473

UniProt ID

P28325

Alternative Names

Cystatin D; Cysteine-Proteinase Inhibitor; Cystatin 5; Cystatin-D; Cystatin-5;

Function

Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S> cathepsin H> cathepsin L> cathepsin B.

Cellular Location

Secreted

References

Mohammed, N. U. G., Khaleel, F. M., & Gorial, F. I. (2021). Cystatin D as a new diagnostic marker in rheumatoid arthritis. Gene Reports, 23, 101027.

Fujita-Yoshigaki, J., Yokoyama, M., & Katsumata-Kato, O. (2020). Switching of cargo sorting from the constitutive to regulated secretory pathway by the addition of cystatin D sequence in salivary acinar cells. American Journal of Physiology-Gastrointestinal and Liver Physiology, 319(1), G74-G86.

Wang, F., Zhang, C., Ge, W., & Zhang, G. (2019). Up‐regulated CST5 inhibits bone resorption and activation of osteoclasts in rat models of osteoporosis via suppression of the NF‐κB pathway. Journal of Cellular and Molecular Medicine, 23(10), 6744-6754.

Hill, L. J., Di Pietro, V., Hazeldine, J., Davies, D., Toman, E., Logan, A., & Belli, A. (2018). Author Correction: Cystatin D (CST5): An ultra-early inflammatory biomarker of traumatic brain injury. Scientific Reports, 8(1), 1-1.

Hill, L. J., Di Pietro, V., Hazeldine, J., Davies, D., Toman, E., Logan, A., & Belli, A. (2017). Cystatin D (CST5): An ultra-early inflammatory biomarker of traumatic brain injury. Scientific Reports, 7(1), 1-10.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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