Sign in or Register   Sign in or Register
  |  

Rat Anti-CST6 Recombinant Antibody (216820) (CBMAB-C0635-LY)

This product is antibody recognizes CST6. The antibody 216820 immunoassay techniques such as: WB, IP, Neutralization.
See all CST6 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
216820
Antibody Isotype
IgG2b
Application
WB, IP, Neutralization

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Cystatin E/M, Glu29-Val149, Accession # NP_082899
Specificity
Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
cystatin E/M
Introduction
CST6 (Cystatin E/M) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CST1.
Entrez Gene ID
UniProt ID
Function
High affinity inhibitor for cathepsin L, cathepsin L2 (cathepsin V), and legumain (PubMed:30425301).

Involved in the regulation of epidermal cornification, and hair follicle morphogenesis and maintenance (PubMed:30425301).
Biological Process
Anatomical structure morphogenesis Source: ProtInc
Epidermis development Source: Ensembl
Cellular Location
Secreted
Involvement in disease
Ectodermal dysplasia 15, hypohidrotic/hair type (ECTD15):
A form of ectodermal dysplasia, a disorder due to abnormal development of two or more ectodermal structures. ECTD15 is an autosomal recessive form characterized by hypotrichosis and absence of sweating except with extreme exercise. Skin is dry from birth and eczematous lesions may develop in adulthood. Other features include blepharitis and photophobia.
PTM
Substrate for transglutaminases. Acts as an acyl acceptor but not as an acyl donor.

Xu, D., Ding, S., Cao, M., Yu, X., Wang, H., Qiu, D., ... & Li, K. (2021). A Pan-Cancer Analysis of Cystatin E/M Reveals Its Dual Functional Effects and Positive Regulation of Epithelial Cell in Human Tumors. Frontiers in genetics, 1676.

Lalmanach, G., Kasabova-Arjomand, M., Lecaille, F., & Saidi, A. (2021). Cystatin m/e (Cystatin 6): a janus-faced cysteine protease inhibitor with both tumor-suppressing and tumor-promoting functions. Cancers, 13(8), 1877.

Li, X., Liang, Y., Lian, C., Peng, F., Xiao, Y., He, Y., ... & Hu, G. (2021). CST6 protein and peptides inhibit breast cancer bone metastasis by suppressing CTSB activity and osteoclastogenesis. Theranostics, 11(20), 9821.

Eckl, K. M., Gruber, R., Brennan, L., Marriott, A., Plank, R., Moosbrugger-Martinz, V., ... & Schmuth, M. (2021). Cystatin M/E variant causes autosomal dominant keratosis follicularis spinulosa decalvans by dysregulating cathepsins L and V. Frontiers in Genetics, 12, 1227.

Gai, D., Stewart, J. P., Shen, X., Chen, J. R., Li, C., Peng, B., ... & Zhan, F. (2020). CST6 Is a Small Autocrine Molecule That Targets Myeloma Growth and Bone Destruction. Blood, 136, 21.

Li, Q., Zheng, Z. C., Ni, C. J., Jin, W. X., Jin, Y. X., Chen, Y., ... & Cai, Y. F. (2018). Correlation of cystatin E/M with clinicopathological features and prognosis in triple-negative breast cancer. Annals of Clinical & Laboratory Science, 48(1), 40-44.

Wallin, H., Apelqvist, J., Andersson, F., Ekström, U., & Abrahamson, M. (2017). Low-level internalization of cystatin E/M affects legumain activity and migration of melanoma cells. Journal of Biological Chemistry, 292(35), 14413-14424.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Rat Anti-CST6 Recombinant Antibody (216820)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare