Sign in or Register   Sign in or Register
  |  

Mouse Anti-CTBP1 Antibody (1A1) (CBMAB-0250-YC)

Provided herein are mouse monoclonal antibodies against Human CTBP1. The antibody clone 1A1 can be used for immunoassay techniques, such as IP and MA.
See all CTBP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A1
Antibody Isotype
IgG1
Application
IP, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
C-Terminal Binding Protein 1
Introduction
CTBP1 (C-terminal binding protein 1) is a protein that binds to the C-terminus of adenovirus E1A proteins. It and the related protein CTBP2 were later shown to function as transcriptional corepressors and may play a role during cellular proliferation. CTBP1 and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development.
Entrez Gene ID
1487
UniProt ID
Q13363
Alternative Names
C-Terminal Binding Protein 1; Brefeldin A-Ribosylated Substrate; EC 1.1.1.158; EC 1.1.1.-; EC 1.1.1; CtBP1; BARS; CTBP
Function
Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.
Biological Process
Chromatin silencing Source: BHF-UCL
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of histone acetylation Source: BHF-UCL
Negative regulation of histone H4 acetylation Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of histone deacetylation Source: BHF-UCL
Protein phosphorylation Source: ProtInc
Regulation of cell cycle Source: BHF-UCL
Viral genome replication Source: ProtInc
White fat cell differentiation Source: UniProtKB
Cellular Location
Cytoplasm; Nucleus
Involvement in disease
Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome (HADDTS):
An autosomal dominant disorder characterized by delayed motor development, intellectual disability, failure to thrive, hypotonia, ataxia, and tooth enamel defects.
PTM
The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation.
ADP-ribosylated; when cells are exposed to brefeldin A.
Sumoylation on Lys-428 is promoted by the E3 SUMO-protein ligase CBX4.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CTBP1 Antibody (1A1)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare