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Mouse Anti-CTDP1 Recombinant Antibody (CBYY-C2208) (CBMAB-C3646-YY)

This product is mouse antibody that recognizes CTDP1. The antibody CBYY-C2208 can be used for immunoassay techniques such as: ELISA, IHC-P, WB
See all CTDP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C2208
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein A purified
Preservative
PBS, pH 7.2
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
Entrez Gene ID
9150
UniProt ID
Q9Y5B0
Alternative Names
Connective Tissue Growth Factor; Hypertrophic Chondrocyte-Specific Protein 24; Insulin-Like Growth Factor-Binding Protein 8; IGF-Binding Protein 8; CCN Family Member 2; IGFBP-8;
Function
Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation.
Biological Process
Cell division Source: UniProtKB-KW
Dephosphorylation of RNA polymerase II C-terminal domain Source: GO_Central
Exit from mitosis Source: UniProtKB
Negative regulation of cell growth involved in cardiac muscle cell development Source: Ensembl
Positive regulation by host of viral transcription Source: CAFA
Positive regulation of viral transcription Source: Reactome
Protein dephosphorylation Source: UniProtKB
Transcription by RNA polymerase II Source: Reactome
Transcription elongation from RNA polymerase II promoter Source: Reactome
Cellular Location
Nucleus; Centrosome; Spindle pole; Midbody. Found at centrosomes in prometaphase, at spindle and spindle poles in metaphase and at spindle midzone and midbody in anaphase and telophase-G1 respectively.
Involvement in disease
Congenital cataracts, facial dysmorphism, and neuropathy (CCFDN):
An autosomal recessive developmental disorder characterized by a complex clinical phenotype with seemingly unrelated features involving multiple organs and systems. Developmental abnormalities include congenital cataracts and microcorneae, hypomyelination of the peripheral nervous system, impaired physical growth, delayed early motor and intellectual development, facial dysmorphism and hypogonadism. Central nervous system involvement, with cerebral and spinal cord atrophy, may be the result of disrupted development with superimposed degenerative changes. Affected individuals are prone to severe rhabdomyolysis after viral infections and to serious complications related to general anesthesia (such as pulmonary edema and epileptic seizures).
PTM
Phosphorylated. In the presence of TFIIF, the phosphorylated form has an increased CTD phosphatase activity. The phosphorylation is required for the physical interaction with GTF2F1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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