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Mouse Anti-CCN2 Recombinant Antibody (13j27) (CBMAB-C2928-LY)

This product is antibody recognizes CTGF. The antibody 13j27 immunoassay techniques such as: ELISA, ICC, IHC-F, WB.
See all CCN2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
13j27
Antibody Isotype
IgG
Application
ELISA, ICC, IHC-F, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.05% sodium azide
Concentration
0.5 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cellular communication network factor 2
Introduction
CTGF (Connective Tissue Growth Factor) is a Protein Coding gene. Diseases associated with CTGF include Systemic Scleroderma and Renal Fibrosis. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PAK Pathway. Gene Ontology (GO) annotations related to this gene include growth factor activity and integrin binding.
An important paralog of this gene is NOV.
Entrez Gene ID
1490
UniProt ID
P29279
Alternative Names
Connective Tissue Growth Factor; Hypertrophic Chondrocyte-Specific Protein 24; Insulin-Like Growth Factor-Binding Protein 8; IGF-Binding Protein 8; CCN Family Member 2; IGFBP-8;
Function
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.
Biological Process
Aging Source: Ensembl
Angiogenesis Source: Ensembl
Cartilage condensation Source: Ensembl
Cell adhesion Source: GO_Central
Cell differentiation Source: Ensembl
Cell-matrix adhesion Source: Ensembl
Cell migration Source: Ensembl
Chondrocyte proliferation Source: Ensembl
Cytosolic calcium ion transport Source: Ensembl
DNA biosynthetic process Source: UniProtKB-KW
Epidermis development Source: ProtInc
Extracellular matrix constituent secretion Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: Ensembl
Integrin-mediated signaling pathway Source: Ensembl
Intracellular signal transduction Source: Ensembl
Lung development Source: Ensembl
Negative regulation of cell death Source: GO_Central
Negative regulation of gene expression Source: Ensembl
Ossification Source: Ensembl
Positive regulation of cardiac muscle contraction Source: Ensembl
Positive regulation of cell activation Source: Ensembl
Positive regulation of cell death Source: Ensembl
Positive regulation of cell differentiation Source: BHF-UCL
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of collagen biosynthetic process Source: Ensembl
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
Positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Positive regulation of G0 to G1 transition Source: Ensembl
Positive regulation of gene expression Source: Ensembl
Positive regulation of JNK cascade Source: BHF-UCL
Positive regulation of protein phosphorylation Source: Ensembl
Positive regulation of stress fiber assembly Source: BHF-UCL
Reactive oxygen species metabolic process Source: Ensembl
Regulation of chondrocyte differentiation Source: Ensembl
Response to amino acid Source: Ensembl
Response to anoxia Source: Ensembl
Response to estradiol Source: Ensembl
Response to fatty acid Source: Ensembl
Response to glucose Source: Ensembl
Response to mineralocorticoid Source: Ensembl
Response to peptide hormone Source: Ensembl
Response to wounding Source: ProtInc
Signal transduction Source: GO_Central
Tissue homeostasis Source: Ensembl
Transcription initiation from RNA polymerase II promoter Source: Reactome
Cellular Location
Extracellular matrix; Secreted

Xu, Z., Jin, Y., Gao, Z., Zeng, Y., Du, J., Yan, H., ... & Luo, P. (2021). Autophagic degradation of CCN2 (cellular communication network factor 2) causes cardiotoxicity of sunitinib. Autophagy, 1-22.

Leguit, R. J., Raymakers, R. A., Hebeda, K. M., & Goldschmeding, R. (2021). CCN2 (Cellular Communication Network factor 2) in the bone marrow microenvironment, normal and malignant hematopoiesis. Journal of cell communication and signaling, 1-32.

Takeuchi-Igarashi, H., Tachibana, T., Murakashi, E., Kubota, S., & Numabe, Y. (2021). Effect of cellular communication network factor 2/connective tissue growth factor on tube formation by endothelial cells derived from human periodontal ligaments. Archives of Oral Biology, 132, 105279.

Rebolledo, D. L., Lipson, K. E., & Brandan, E. (2021). Driving fibrosis in neuromuscular diseases: Role and regulation of connective tissue growth factor (CCN2/CTGF). Matrix Biology Plus, 100059.

Akashi, S., Nishida, T., Mizukawa, T., Kawata, K., Takigawa, M., Iida, S., & Kubota, S. (2020). Regulation of cellular communication network factor 2 (CCN2) in breast cancer cells via the cell-type dependent interplay between CCN2 and glycolysis. Journal of Oral Biosciences, 62(3), 280-288.

Okusha, Y., Eguchi, T., Tran, M. T., Sogawa, C., Yoshida, K., Itagaki, M., ... & Okamoto, K. (2020). Extracellular vesicles enriched with moonlighting metalloproteinase are highly transmissive, pro-tumorigenic, and trans-activates cellular communication network factor (CCN2/CTGF): CRISPR against cancer. Cancers, 12(4), 881.

Falke, L. L., He, N., de Sousa Lopes, S. M. C., Broekhuizen, R., Lyons, K., Nguyen, T. Q., & Goldschmeding, R. (2020). FoxD1-driven CCN2 deletion causes axial skeletal deformities, pulmonary hypoplasia, and neonatal asphyctic death. Journal of cell communication and signaling, 1-5.

Barbe, M. F., Hilliard, B. A., Amin, M., Harris, M. Y., Hobson, L. J., Cruz, G. E., & Popoff, S. N. (2020). Blocking CTGF/CCN2 reduces established skeletal muscle fibrosis in a rat model of overuse injury. The FASEB Journal, 34(5), 6554-6569.

Inoue, T., Kusano, T., Amano, H., Nakamoto, H., & Okada, H. (2019). Cellular communication network factor 2 (CCN2) promotes the progression of acute kidney injury to chronic kidney disease. Biochemical and biophysical research communications, 517(1), 96-102.

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For research use only. Not intended for any clinical use.

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