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Mouse Anti- CTLA-4 Recombinant Antibody (BN13) (CBMAB-0932-LY)

This product is mouse antibody recognizes human CTLA-4 (CD152). The antibody BN13 immunoassay techniques such as: Neutralization, FC.
Host Animal
Mouse
Application
Neutralization, FC
Antibody Isotype
IgG2a
Specificity
Human
Cross Reactivity
Human
Clone
BN13
Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
Introduction
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Alternative Name
CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3
Entrez Gene ID
UniProt ID
Cat CBMAB-0932-LY
Conjugates
Size
Price $
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