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Mouse Anti-CTNNA1 Recombinant Antibody (15D9) (CBMAB-C3267-LY)

This product is antibody recognizes CTNNA1. The antibody 15D9 immunoassay techniques such as: ELISA, ICC/IF, IP, WB.
See all CTNNA1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
15D9
Antibody Isotype
IgG1
Application
ELISA, ICC/IF, IP, WB

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Catenin Alpha 1
Introduction
CTNNA1 (Catenin Alpha 1) is a Protein Coding gene. Diseases associated with CTNNA1 include Macular Dystrophy, Patterned, 2 and Butterfly-Shaped Pigment Dystrophy. Among its related pathways are N-cadherin signaling events and PAK Pathway. Gene Ontology (GO) annotations related to this gene include actin filament binding.
An important paralog of this gene is CTNNA2.
Entrez Gene ID
Human1495
Mouse12385
Rat307505
UniProt ID
HumanP35221
MouseP26231
RatQ5U302
Function
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity).

May play a crucial role in cell differentiation.
Biological Process
Actin filament organization Source: InterPro
Adherens junction organization Source: Reactome
Aging Source: Ensembl
Apical junction assembly Source: UniProtKB
Axon regeneration Source: Ensembl
Cell adhesion Source: ProtInc
Cell-cell adhesion Source: GO_Central
Cell migration Source: GO_Central
Cellular protein localization Source: Ensembl
Cellular response to indole-3-methanol Source: UniProtKB
Epithelial cell-cell adhesion Source: Ensembl
Establishment or maintenance of cell polarity Source: Ensembl
Gap junction assembly Source: Ensembl
Male gonad development Source: Ensembl
Negative regulation of cell motility Source: Ensembl
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
Negative regulation of integrin-mediated signaling pathway Source: Ensembl
Negative regulation of neuroblast proliferation Source: Ensembl
Negative regulation of protein localization to nucleus Source: UniProtKB
Odontogenesis of dentin-containing tooth Source: Ensembl
Ovarian follicle development Source: Ensembl
Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
Positive regulation of muscle cell differentiation Source: Reactome
Positive regulation of smoothened signaling pathway Source: Ensembl
Response to estrogen Source: Ensembl
Cellular Location
Isoform 1: Cell membrane; Cytoskeleton; Adherens junction; Cell junction. Found at cell-cell boundaries and probably at cell-matrix boundaries.
Isoform 3: Cell membrane
Involvement in disease
Germline CTNNA1 truncating mutations have been detected in patients with hereditary diffuse gastric cancer (HDGC) and may play a role in disease susceptibility. Diffuse gastric cancer is a malignant disease characterized by poorly differentiated infiltrating lesions resulting in thickening of the stomach. Malignant tumors start in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body.
Macular dystrophy, patterned, 2 (MDPT2):
A form of retinal patterned dystrophy, a heterogeneous group of macular disorders caused by abnormal accumulation of lipofuscin in the retinal pigment epithelium. Lipofuscin distribution can show various shapes that define different types of macular dystrophy, including reticular (fishnet-like) dystrophy, macroreticular (spider-shaped) dystrophy and butterfly-shaped pigment dystrophy. MDPT2 is an autosomal dominant form characterized by bilateral accumulation of pigment in the macular area that resembles the wings of a butterfly.
PTM
Sumoylated.
Phosphorylation seems to contribute to the strength of cell-cell adhesion rather than to the basic capacity for cell-cell adhesion.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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