Mouse Anti-CUZD1 Recombinant Antibody (CBWJC-2089) (CBMAB-C2777WJ)

This product is a Mouse antibody that recognizes CUZD1. This antibody CBWJC-2089 can be used for immunoassay techniques such as: WB, ELISA, IHC.
See all CUZD1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBWJC-2089

Antibody Isotype

IgG2b, κ

Application

WB, ELISA, IHC

Basic Information

Immunogen

Ovalbumin-conjugated synthetic peptide - RHFVNQRADY

Specificity

Human

Antibody Isotype

IgG2b, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

CUB And Zona Pellucida Like Domains 1

Introduction

CUZD1 (CUB And Zona Pellucida Like Domains 1) is a Protein Coding gene.

Entrez Gene ID

50624

UniProt ID

Q86UP6

Alternative Names

CUB And Zona Pellucida Like Domains 1; CUB And ZP Domain-Containing Protein 1; Transmembrane Protein UO-44; CUB And Zona Pellucida-Like Domain-Containing Protein 1; CUB And Zona Pellucida-Like Domains 1; Estrogen Regulated Gene 1;

Function

Localized to zymogen granules, where it functions in trypsinogen activation (By similarity).

May indirectly regulate cell motility, cell-cell and cell/extracellular matrix interactions (PubMed:15184879).

Biological Process

Cell adhesion Source: UniProtKB-KW
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Trypsinogen activation Source: UniProtKB

Cellular Location

Zymogen granule membrane

Topology

Lumenal: 25-568
Helical: 569-589
Cytoplasmic: 590-607

References

Mapes, J., Anandan, L., Li, Q., Neff, A., Clevenger, C. V., Bagchi, I. C., & Bagchi, M. K. (2018). Aberrantly high expression of the CUB and zona pellucida-like domain-containing protein 1 (CUZD1) in mammary epithelium leads to breast tumorigenesis. Journal of Biological Chemistry, 293(8), 2850-2864.

Farkona, S., Soosaipillai, A., Filippou, P., Liaskos, C., Bogdanos, D. P., Diamandis, E. P., & Blasutig, I. M. (2017). Novel immunoassays for detection of CUZD1 autoantibodies in serum of patients with inflammatory bowel diseases. Clinical Chemistry and Laboratory Medicine (CCLM), 55(10), 1574-1581.

Mapes, J., Li, Q., Kannan, A., Anandan, L., Laws, M., Lydon, J. P., ... & Bagchi, M. K. (2017). CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy. PLoS genetics, 13(3), e1006654.

Farkona, S., Soosaipillai, A., Filippou, P., Korbakis, D., Serra, S., Rückert, F., ... & Blasutig, I. M. (2017). Generation of monoclonal antibodies and development of an immunofluorometric assay for the detection of CUZD1 in tissues and biological fluids. Clinical Biochemistry, 50(18), 1168-1174.

Mapes, J. E. (2017). Investigation of the role of CUZD1-STAT5 signaling in mammary gland development and breast cancer (Doctoral dissertation, University of Illinois at Urbana-Champaign).

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-CUZD1 Recombinant Antibody (CBWJC-3465)

Mouse Anti-CUZD1 Recombinant Antibody (M4P6G6)

Mouse Anti-CUZD1 Recombinant Antibody (CBXC-3145)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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