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Mouse Anti-CWC27 Recombinant Antibody (CBWJC-3467) (CBMAB-C4697WJ)

This product is a Mouse antibody that recognizes CWC27. This antibody CBWJC-3467 can be used for immunoassay techniques such as: IHC.
See all CWC27 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJC-3467
Antibody Isotype
IgG1
Application
IHC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to aa145-472 of human CWC27(NP_005860) produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS (PH 7.3), 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CWC27 Spliceosome Associated Protein Homolog
Introduction
CWC27 (CWC27 Spliceosome Associated Protein Homolog) is a Protein Coding gene. Diseases associated with CWC27 include Retinitis Pigmentosa With Or Without Skeletal Anomalies and Retinitis Pigmentosa. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is PPIL4.
Entrez Gene ID
UniProt ID
Alternative Names
CWC27 Spliceosome Associated Protein Homolog; Serologically Defined Colon Cancer Antigen 10; Antigen NY-CO-10; PPIase CWC27; SDCCAG10; CWC27 Spliceosome-Associated Protein Homolog (S. Cerevisiae); Peptidyl-Prolyl Cis-Trans Isomerase CWC27 Homolog; CWC27 Spliceosome-Associated Protein Homolog;
Function
As part of the spliceosome, plays a role in pre-mRNA splicing (PubMed:29360106).

Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357).
Biological Process
mRNA splicing, via spliceosome Source: Reactome
Protein folding Source: InterPro
Protein peptidyl-prolyl isomerization Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Retinitis pigmentosa with or without skeletal anomalies (RPSKA):
An autosomal recessive disease characterized by retinal degeneration, brachydactyly, short stature, craniofacial dysmorphism, and neurologic defects. Retinal defects are consistent with retinitis pigmentosa in most patients. Neurologic manifestations include mild-to-moderate intellectual disability and psychomotor retardation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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