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Rabbit Anti-CXADR Recombinant Antibody (CBFYC-2485) (CBMAB-C2558-FY)

This product is rabbit antibody that recognizes CXADR. The antibody CBFYC-2485 can be used for immunoassay techniques such as: ELISA, IHC-P.
See all CXADR antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
CBFYC-2485
Antibody Isotype
IgG
Application
ELISA, IHC-P

Basic Information

Immunogen
Recombinant Mouse CXADR protein
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CXADR, Ig-Like Cell Adhesion Molecule
Introduction
CXADR (CXADR, Ig-Like Cell Adhesion Molecule) is a Protein Coding gene. Diseases associated with CXADR include Myocarditis and Dilated Cardiomyopathy. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include identical protein binding and integrin binding. An important paralog of this gene is ENSG00000277666.
Entrez Gene ID
13052
UniProt ID
P97792
Alternative Names
CAR; MCAR; MCVADR; AU016810; AW553441; 2610206D03Rik
Function
Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.

(Microbial infection) Acts as a receptor for adenovirus type C.

(Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6.
Biological Process
Actin cytoskeleton reorganization Source: UniProtKB
AV node cell-bundle of His cell adhesion involved in cell communication Source: BHF-UCL
AV node cell to bundle of His cell communication Source: UniProtKB
Cardiac muscle fiber development Source: UniProtKB
Cell-cell junction organization Source: UniProtKB
Defense response to virus Source: UniProtKB
Epithelial structure maintenance Source: UniProtKB
Gamma-delta T cell activation Source: UniProtKB
Germ cell migration Source: UniProtKB
Heart development Source: UniProtKB
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Homotypic cell-cell adhesion Source: UniProtKB
Leukocyte migration Source: Reactome
Mitochondrion organization Source: UniProtKB
Neutrophil chemotaxis Source: UniProtKB
Regulation of AV node cell action potential Source: BHF-UCL
Regulation of immune response Source: Reactome
Transepithelial transport Source: UniProtKB
Cellular Location
Isoform 1: Cell membrane; Basolateral cell membrane; Tight junction; Adherens junction. In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions (PubMed:12297051). In airway epithelial cells localized to basolateral membrane but not to apical surface (PubMed:11316797).
Isoform 3&4&5: Secreted
Topology
Extracellular: 20-237
Helical: 238-258
Cytoplasmic: 259-365
PTM
N-glycosylated.
Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane.

Zhang, Y., & Lui, W. Y. (2021). Coxsackievirus and Adenovirus Receptor (CXADR): Recent Findings and Its Role and Regulation in Spermatogenesis. Molecular Mechanisms in Spermatogenesis, 95-109.

Han, X., Zhao, Z. A., Yan, S., Lei, W., Wu, H., Lu, X. A., ... & Hu, S. (2020). CXADR‐like membrane protein protects against heart injury by preventing excessive pyroptosis after myocardial infarction. Journal of cellular and molecular medicine, 24(23), 13775-13788.

Nilchian, A., Johansson, J., Ghalali, A., Asanin, S. T., Santiago, A., Rosencrantz, O., ... & Fuxe, J. (2019). CXADR-mediated formation of an AKT inhibitory signalosome at tight junctions controls epithelial–mesenchymal plasticity in breast cancer. Cancer Research, 79(1), 47-60.

Kobayashi, T., Matsugo, H., Maruyama, J., Kamiki, H., Takada, A., Maeda, K., ... & Horimoto, T. (2019). Characterization of a novel species of adenovirus from Japanese microbat and role of CXADR as its entry factor. Scientific reports, 9(1), 1-13.

Jeong, Y., Ock, S. A., Yoo, J. G., Yu, D. Y., & Choi, I. (2019). The Cxadr–Adam10 complex plays pivotal roles in tight junction integrity and early trophoblast development in mice. Molecular Reproduction and Development, 86(11), 1628-1638.

Outhwaite, J. E., Patel, J., & Simmons, D. G. (2019). Secondary placental defects in Cxadr mutant mice. Frontiers in physiology, 622.

Kawada, M., Sakamoto, S., Inoue, H., Kaneko, M., Ogasawara, S., Kajikawa, M., ... & Kato, Y. (2019). Abstract B097: Development of a mouse-human chimeric antibody against human CXADR having a potent antitumor activity in animal models.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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