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Rat Anti-CXCL14 Recombinant Antibody (17P3) (CBMAB-C3436-LY)

This product is antibody recognizes CXCL14. The antibody 17P3 immunoassay techniques such as: WB.
See all CXCL14 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
17P3
Antibody Isotype
IgG2
Application
WB

Basic Information

Immunogen
Mouse recombinant protein CXCL14
Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
C-X-C Motif Chemokine Ligand 14
Introduction
CXCL14 (C-X-C Motif Chemokine Ligand 14) is a Protein Coding gene. Diseases associated with CXCL14 include Squamous Cell Carcinoma, Head And Neck and Pelvic Lipomatosis. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity.
Entrez Gene ID
57266
UniProt ID
Q9WUQ5
Function
Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell-cell signaling Source: ProtInc
Chemotaxis Source: ProtInc
Inner ear development Source: Ensembl
Killing of cells of other organism Source: UniProtKB
Negative regulation of myoblast differentiation Source: Ensembl
Positive regulation of natural killer cell chemotaxis Source: Ensembl
Signal transduction Source: ProtInc
Cellular Location
Secreted
PTM
Ubiquitinated, followed by degradation by the proteasome.

Chen, L., Lei, Y., & Zhang, L. (2021). Role of CXC motif chemokine ligand 14 promoter region DNA methylation and single nucleotide polymorphism in influenza A severity. Respiratory Medicine, 185, 106462.

Matsushita, Y., Hasegawa, Y., Takebe, N., Onodera, K., Shozushima, M., Oda, T., ... & Ishigaki, Y. (2021). Serum C‐X‐C motif chemokine ligand 14 levels are associated with serum C‐peptide and fatty liver index in type 2 diabetes mellitus patients. Journal of Diabetes Investigation, 12(6), 1042-1049.

Wang, C., Zhao, N., Sato, F., Tanimoto, K., Okada, H., Liu, Y., & Bhawal, U. K. (2021). The roles of Y-box-binding protein (YB)-1 and CXC motif chemokine ligand 14 (CXCL14) in the progression of prostate cancer via extracellular-signal-regulated kinase (ERK) signaling. Bioengineered, 12(2), 9128-9139.

Cereijo, R., Quesada-Lopez, T., Gavalda-Navarro, A., Tarascó, J., Pellitero, S., Reyes, M., ... & Villarroya, F. (2021). The chemokine CXCL14 is negatively associated with obesity and concomitant type-2 diabetes in humans. International Journal of Obesity, 45(3), 706-710.

Qi, J., Li, J., Wang, Y., Wang, W., Zhu, Q., He, Y., ... & Sun, Y. (2021). Novel role of CXCL14 in modulating STAR expression in luteinized granulosa cells: implication for progesterone synthesis in PCOS patients. Translational Research, 230, 55-67.

García-Beltran, C., Cereijo, R., Quesada-López, T., Malpique, R., López-Bermejo, A., de Zegher, F., ... & Villarroya, F. (2020). Reduced circulating levels of chemokine CXCL14 in adolescent girls with polycystic ovary syndrome: normalization after insulin sensitization. BMJ Open Diabetes Research and Care, 8(1), e001035.

Ko, H. M., Moon, J. S., Shim, H. K., Lee, S. Y., Kang, J. H., Kim, M. S., ... & Kim, S. H. (2020). Inhibitory effect of CXC motif chemokine ligand 14 on the osteogenic differentiation of human periodontal ligament cells through transforming growth factor-beta1. Archives of Oral Biology, 115, 104733.

Yang, X. Y., Ozawa, S., Kato, Y., Maehata, Y., Izukuri, K., Ikoma, T., ... & Hata, R. I. (2019). CXC motif chemokine ligand 14 is a unique multifunctional regulator of tumor progression. International Journal of Molecular Sciences, 20(8), 1872.

Li, L., Li, Q., Wei, L., Wang, Z., Ma, W., Liu, F., ... & Qian, Y. (2019). Chemokine (C‐X‐C motif) ligand 14 contributes to lipopolysaccharide‐induced fibrogenesis in mouse L929 fibroblasts via modulating PPM1A. Journal of Cellular Biochemistry, 120(8), 13372-13381.

Cereijo, R., Gavaldà-Navarro, A., Cairó, M., Quesada-López, T., Villarroya, J., Morón-Ros, S., ... & Villarroya, F. (2018). CXCL14, a brown adipokine that mediates brown-fat-to-macrophage communication in thermogenic adaptation. Cell metabolism, 28(5), 750-763.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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