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Rat Anti-CXCL17 Recombinant Antibody (510614) (CBMAB-C7143-LY)

This product is antibody recognizes CXCL17. The antibody 510614 immunoassay techniques such as: WB.
See all CXCL17 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
510614
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
E. coli-derived recombinant mouse CXCL17/VCC-1 Ser31-Leu119
Specificity
Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
5% trehalose
Concentration
0.5 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
C-X-C Motif Chemokine Ligand 17
Introduction
CXCL17 (C-X-C Motif Chemokine Ligand 17) is a Protein Coding gene. Diseases associated with CXCL17 include Cholera. Among its related pathways are Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions.
Entrez Gene ID
UniProt ID
Function
Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells (PubMed:16455961, PubMed:23115081).

Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081).

Acts as an anti-inflammatory in the stomach (PubMed:23115081).

May play a role in the innate defense against infections (PubMed:17307946).

Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed:25411203).

4-Cys CXCL17:
seems exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.
Biological Process
Activation of MAPK activity Source: UniProtKB
Angiogenesis Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Macrophage chemotaxis Source: GO_Central
Negative regulation of inflammatory response Source: UniProtKB
Positive regulation of macrophage chemotaxis Source: UniProtKB
Positive regulation of monocyte chemotaxis Source: UniProtKB
Positive regulation of vascular endothelial growth factor production Source: UniProtKB
Cellular Location
Secreted
PTM
Likely to undergo an endoproteolytic process to form a four-cysteine-containing mature peptide with a canonical CXC chemokine scaffold after secretion.

Wang, L. P., Lin, J., Ma, X. Q., Xu, D. Y., Shi, C. F., Wang, W., & Jiang, X. J. (2021). Exosomal DLX6-AS1 from hepatocellular carcinoma cells induces M2 macrophage polarization to promote migration and invasion in hepatocellular carcinoma through microRNA-15a-5p/CXCL17 axis. Journal of Experimental & Clinical Cancer Research, 40(1), 1-16.

Choreño-Parra, J. A., Jiménez-Álvarez, L. A., Ramírez-Martínez, G., Sandoval-Vega, M., Salinas-Lara, C., Sánchez-Garibay, C., ... & Zúñiga, J. (2021). CXCL17 is a specific diagnostic biomarker for severe pandemic influenza A (H1N1) that predicts poor clinical outcome. Frontiers in immunology, 12.

Fermin, J. M., Alam, M. M., Gu, X., Asarkar, A., Nathan, C. A., & Khandelwal, A. R. (2021). CXCL17 as a prognostic biomarker for aggressive cutaneous squamous cell carcinoma.

Yao, H., Lv, Y., Bai, X., Yu, Z., & Liu, X. (2020). Prognostic value of CXCL17 and CXCR8 expression in patients with colon cancer. Oncology letters, 20(3), 2711-2720.

Choreño-Parra, J. A., Thirunavukkarasu, S., Zúñiga, J., & Khader, S. A. (2020). The protective and pathogenic roles of CXCL17 in human health and disease: Potential in respiratory medicine. Cytokine & growth factor reviews, 53, 53-62.

Liu, W., Xie, X., & Wu, J. (2020). Mechanism of lung adenocarcinoma spine metastasis induced by CXCL17. Cellular Oncology, 43(2), 311-320.

Rojewska, E., Ciapała, K., & Mika, J. (2019). Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced morphine analgesia in a mouse neuropathic pain model. Pharmacological Reports, 71(1), 139-148.

Khandelwal, A. R., Alam, M. M., Moore-Medlin, T., Savage, H. A., & Nathan, C. A. O. (2019). Role of the CXCL17-CXCR8 (GPR35) axis in cutaneous squamous cell carcinoma.

Zhang, K., Liang, Y., Feng, Y., Wu, W., Zhang, H., He, J., ... & Zhen, G. (2018). Decreased epithelial and sputum miR-221-3p associates with airway eosinophilic inflammation and CXCL17 expression in asthma. American Journal of Physiology-Lung Cellular and Molecular Physiology, 315(2), L253-L264.

Guo, Y. J., Zhou, Y. J., Yang, X. L., Shao, Z. M., & Ou, Z. L. (2017). The role and clinical significance of the CXCL17-CXCR8 (GPR35) axis in breast cancer. Biochemical and biophysical research communications, 493(3), 1159-1167.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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