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Mouse Anti-CXCL3 Recombinant Antibody (83504) (CBMAB-C8967-LY)

This product is antibody recognizes CXCL3 . The antibody 83504 immunoassay techniques such as: WB, Neutralization, ELISA (Cap).
See all CXCL3 antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
83504
Antibody Isotype
IgG2b
Application
WB, Neutralization, ELISA (Cap)

Basic Information

Immunogen
E. coli-derived recombinant rat CXCL3/CINC-2 alpha/beta, Arg33-Ser100, Accession # Q10746
Specificity
Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
C-X-C Motif Chemokine Ligand 3
Introduction
CXCL3 (C-X-C Motif Chemokine Ligand 3) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity and CXCR chemokine receptor binding. An important paralog of this gene is CXCL2.
Entrez Gene ID
171551
UniProt ID
Q10746
Function
Ligand for CXCR2 (By similarity).

Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cellular response to lipopolysaccharide Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Neutrophil chemotaxis Source: UniProtKB
Cellular Location
Secreted
PTM
N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.

Reyes, N., Figueroa, S., Tiwari, R., & Geliebter, J. (2021). CXCL3 Signaling in the Tumor Microenvironment. Tumor Microenvironment, 15-24.

Lv, Q. Y., Zou, H. Z., Xu, Y. Y., Shao, Z. Y., Wu, R. Q., Li, K. J., ... & Zou, C. L. (2021). Expression levels of chemokine (CXC motif) ligands CXCL1 and CXCL3 as prognostic biomarkers in rectal adenocarcinoma: evidence from Gene Expression Omnibus (GEO) analyses. Bioengineered, 12(1), 3711-3725.

Aguilera-Durán, G., & Romo-Mancillas, A. (2020). Computational study of CXC chemokine receptor (CXCR) 3 binding with its natural agonists chemokine (CXC Motif) ligand (CXCL) 9, 10 and 11 and with synthetic antagonists: Insights of receptor activation towards drug design for vitiligo. Molecules, 25(19), 4413.

Ruan, G. T., Gong, Y. Z., Liao, X. W., Wang, S., Huang, W., Wang, X. K., ... & Gao, F. (2019). Diagnostic and prognostic values of C‑X‑C motif chemokine ligand 3 in patients with colon cancer. Oncology reports, 42(5), 1996-2008.

Kuo, P. T., Zeng, Z., Salim, N., Mattarollo, S., Wells, J. W., & Leggatt, G. R. (2018). The role of CXCR3 and its chemokine ligands in skin disease and cancer. Frontiers in Medicine, 271.

Metzemaekers, M., Vanheule, V., Janssens, R., Struyf, S., & Proost, P. (2018). Overview of the mechanisms that may contribute to the non-redundant activities of interferon-inducible CXC chemokine receptor 3 ligands. Frontiers in immunology, 8, 1970.

Liu, Q. Z., Ma, W. T., Yang, J. B., Zhao, Z. B., Yan, K., Yao, Y., ... & Lian, Z. X. (2018). The CXC chemokine receptor 3 inhibits autoimmune cholangitis via CD8+ T cells but promotes colitis via CD4+ T cells. Frontiers in immunology, 9, 1090.

Smith, J. S., Alagesan, P., Desai, N. K., Pack, T. F., Wu, J. H., Inoue, A., ... & Rajagopal, S. (2017). CXC motif chemokine receptor 3 splice variants differentially activate beta-arrestins to regulate downstream signaling pathways. Molecular pharmacology, 92(2), 136-150.

Bronger, H., Karge, A., Dreyer, T., Zech, D., Kraeft, S., Avril, S., ... & Schmitt, M. (2017). Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells. Oncology Letters, 13(6), 4224-4230.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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