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Mouse Anti-CXCL5 Recombinant Antibody (S5) (CBMAB-C11380-LY)

The product is antibody recognizes CXCL5. The antibody S5 immunoassay techniques such as: WB.
See all CXCL5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
S5
Antibody Isotype
IgG1, κ
Application
WB

Basic Information

Immunogen
CXCL5 (AAH08376, 1 a.a. ~ 115 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
C-X-C Motif Chemokine Ligand 5
Introduction
CXCL5 (C-X-C Motif Chemokine Ligand 5) is a Protein Coding gene. Diseases associated with CXCL5 include Pediatric Ulcerative Colitis and Acute Cervicitis. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity and CXCR chemokine receptor binding. An important paralog of this gene is CXCL6.
Entrez Gene ID
6374
UniProt ID
P42830
Alternative Names
C-X-C Motif Chemokine Ligand 5; Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 5 (Epithelial-Derived Neutrophil-Activating Peptide 78); Epithelial-Derived Neutrophil-Activating Protein 78; Neutrophil-Activating Peptide ENA-78; Chemokine (C-X-C Motif) Ligand 5; SCYB5; Neutrophil-Activating Protein 78;
Function
Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: GO_Central
Cell-cell signaling Source: ProtInc
Cellular response to lipopolysaccharide Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Positive regulation of cell population proliferation Source: ProtInc
Signal transduction Source: ProtInc
Cellular Location
Secreted
PTM
N-terminal processed forms ENA-78(8-78) and ENA-78(9-78) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.

Kalchiem-Dekel, O., Yao, X., Barochia, A. V., Kaler, M., Figueroa, D. M., Karkowsky, W. B., ... & Levine, S. J. (2020). Apolipoprotein E signals via TLR4 to induce CXCL5 secretion by asthmatic airway epithelial cells. American Journal of Respiratory Cell and Molecular Biology, 63(2), 185-197.

Bai, L., Yao, N., Qiao, G., Wu, L., & Ma, X. (2020). CXCL5 contributes to the tumorigenicity of cervical cancer and is post-transcriptionally regulated by miR-577. International Journal of Clinical and Experimental Pathology, 13(12), 2984.

Zhang, W., Wang, H., Sun, M., Deng, X., Wu, X., Ma, Y., ... & Miao, L. (2020). CXCL5/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target. Cancer Communications, 40(2-3), 69-80.

Cui, D., Zhao, Y., & Xu, J. (2019). Activation of CXCL5-CXCR2 axis promotes proliferation and accelerates G1 to S phase transition of papillary thyroid carcinoma cells and activates JNK and p38 pathways. Cancer biology & therapy, 20(5), 608-616.

Wang, C. Y., Shang, M., Zhou, C. L., Feng, L. Z., Zhou, Q. S., & Hu, K. (2019). Mechanism of Cxc chemokine ligand 5 (CXCL5)/Cxc chemokine receptor 2 (CXCR2) bio-axis in mice with acute respiratory distress syndrome. Medical science monitor: international medical journal of experimental and clinical research, 25, 5299.

Lim, W. K., Chai, X., Ghosh, S., Ray, D., Wang, M., Rasheed, S. A. K., & Casey, P. J. (2019). Gα-13 induces CXC motif chemokine ligand 5 expression in prostate cancer cells by transactivating NF-κB. Journal of Biological Chemistry, 294(48), 18192-18206.

Wang, C., Li, A., Yang, S., Qiao, R., Zhu, X., & Zhang, J. (2018). CXCL5 promotes mitomycin C resistance in non-muscle invasive bladder cancer by activating EMT and NF-κB pathway. Biochemical and biophysical research communications, 498(4), 862-868.

O'Sullivan, S. A., O'Sullivan, C., Healy, L. M., Dev, K. K., & Sheridan, G. K. (2018). Sphingosine 1‐phosphate receptors regulate TLR 4‐induced CXCL 5 release from astrocytes and microglia. Journal of neurochemistry, 144(6), 736-747.

Zhao, Y., Zhang, X., Zhao, H., Wang, J., & Zhang, Q. (2018). CXCL5 secreted from adipose tissue‑derived stem cells promotes cancer cell proliferation. Oncology Letters, 15(2), 1403-1410.

Smith, K. J., Boyer, J. A., Muku, G. E., Murray, I. A., Gowda, K., Desai, D., ... & Perdew, G. H. (2017). Editor’s highlight: Ah receptor activation potentiates neutrophil chemoattractant (CXC motif) ligand 5 expression in keratinocytes and skin. Toxicological Sciences, 160(1), 83-94.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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