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Mouse Anti-CXCL6 Recombinant Antibody (CBFYC-2521) (CBMAB-C2595-FY)

This product is mouse antibody that recognizes CXCL6. The antibody CBFYC-2521 can be used for immunoassay techniques such as: FC.
See all CXCL6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-2521
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.5% BSA
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
Introduction
CXCL6 (C-X-C Motif Chemokine Ligand 6) is a Protein Coding gene. Diseases associated with CXCL6 include Mastitis and Rheumatoid Arthritis. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include heparin binding and CXCR chemokine receptor binding. An important paralog of this gene is CXCL5.
Entrez Gene ID
6372
UniProt ID
P80162
Alternative Names
C-X-C Motif Chemokine Ligand 6; Granulocyte Chemotactic Protein 2; Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 6 (Granulocyte Chemotactic Protein 2); Chemokine (C-X-C Motif) Ligand 6 (Granulocyte Chemotactic Protein 2); Small-Inducible Cytokine B6; Chemokine Alpha 3; SCYB6
Function
Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cellular response to lipopolysaccharide Source: UniProtKB
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Defense response to bacterium Source: UniProtKB-KW
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Leukocyte homeostasis Source: Ensembl
Neutrophil activation Source: UniProtKB
Neutrophil chemotaxis Source: UniProtKB
Regulation of chemokine production Source: Ensembl
Regulation of neutrophil mediated killing of gram-negative bacterium Source: Ensembl
Signal transduction Source: ProtInc
Cellular Location
Secreted

Jiang, Y., Xi, Y., Li, Y., Zuo, Z., Zeng, C., Fan, J., ... & Guo, Y. (2022). Ethanol promoting the upregulation of CXC Motif Chemokine Ligand 1（ CXCL1） and CXC Motif Chemokine Ligand 6（ CXCL6） in models of early alcoholic liver disease. Bioengineered, 13(3), 4688-4701.

Wang, S. Z., Zhang, Y. L., & Shi, H. B. (2021). Potential Repressive Impact of microRNA-20a on Renal Tubular Damage in Diabetic Kidney Disease by Targeting CXC Motif Chemokine Ligand 6. Archives of Medical Research, 52(1), 58-68.

Wang, X., Dai, Y., Zhang, X., Pan, K., Deng, Y., Wang, J., & Xu, T. (2021). CXCL6 regulates cell permeability, proliferation, and apoptosis after ischemia–reperfusion injury by modulating Sirt3 expression via AKT/FOXO3a activation. Cancer Biology & Therapy, 22(1), 30-39.

Zheng, S., Shen, T., Liu, Q., Liu, T., Tuerxun, A., Zhang, Q., ... & Lu, X. (2021). CXCL6 fuels the growth and metastases of esophageal squamous cell carcinoma cells both in vitro and in vivo through upregulation of PD‐L1 via activation of STAT3 pathway. Journal of Cellular Physiology, 236(7), 5373-5386.

Sun, C., Li, G., & Liu, M. (2020). A novel circular RNA, circ_0005394, predicts unfavorable prognosis and contributes to hepatocellular carcinoma progression by regulating miR-507/E2F3 and miR-515-5p/CXCL6 signaling pathways. OncoTargets and therapy, 13, 6171.

Liu, G., An, L., Zhang, H., Du, P., & Sheng, Y. (2019). Activation of CXCL6/CXCR1/2 axis promotes the growth and metastasis of osteosarcoma cells in vitro and in vivo. Frontiers in pharmacology, 10, 307.

Yamamoto, Y., Kuroda, K., Sera, T., Sugimoto, A., Kushiyama, S., Nishimura, S., ... & Yashiro, M. (2019). The clinicopathological significance of the CXCR2 ligands, CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, and CXCL8 in gastric cancer. Anticancer research, 39(12), 6645-6652.

Shen, W., Xie, X. Y., Liu, M. R., & Wang, L. L. (2019). MicroRNA-101-5p inhibits the growth and metastasis of cervical cancer cell by inhibiting CXCL6. Eur Rev Med Pharmacol Sci, 23(5), 1957-1968.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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