Sign in or Register   Sign in or Register
  |  

Rat Anti-CXCR5 Recombinant Antibody (CBYY-I0027) (CBMAB-I0055-YY)

This product is Rat antibody that recognizes CXCR5. The antibody CBYY-I0027 can be used for immunoassay techniques such as: FC
See all CXCR5 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYY-I0027
Antibody Isotype
IgG2a, κ
Application
FC

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
C-X-C Motif Chemokine Receptor 5
Introduction
CXCR5 (C-X-C Motif Chemokine Receptor 5) is a Protein Coding gene. Diseases associated with CXCR5 include Burkitt Lymphoma and Lymphoma. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors.
Entrez Gene ID
UniProt ID
Alternative Names
C-X-C Motif Chemokine Receptor 5; Burkitt Lymphoma Receptor 1, GTP Binding Protein (Chemokine (C-X-C Motif) Receptor 5); Burkitt Lymphoma Receptor 1, GTP-Binding Protein; Chemokine (C-X-C Motif) Receptor 5; Monocyte-Derived Receptor 15; CXC-R5; CXCR-5; MD
Function
Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.
Biological Process
B cell activation Source: UniProtKB-KW
Calcium-mediated signaling Source: GO_Central
Cell chemotaxis Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Leukocyte chemotaxis Source: Ensembl
Lymph node development Source: Ensembl
Positive regulation of cytokinesis Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 1-55
Helical: 56-76
Cytoplasmic: 77-88
Helical: 89-109
Extracellular: 110-124
Helical: 125-145
Cytoplasmic: 146-167
Helical: 168-188
Extracellular: 189-219
Helical: 220-240
Cytoplasmic: 241-259
Helical: 260-280
Extracellular: 281-304
Helical: 305-325
Cytoplasmic: 326-372

Saddala, M. S., Lennikov, A., Mukwaya, A., Yang, X., Tang, S., & Huang, H. (2021). Data mining and network analysis reveals CXC chemokine receptor type 5 is involved in the pathophysiology of age-related macular degeneration. Journal of Biomolecular Structure and Dynamics, 1-10.

Saddala, M. S., Lennikov, A., & Huang, H. (2020). RNA-seq data from CXC chemokine receptor type 5 (CXCR5) gene knockout aged mice with retinal degeneration phenotype. Data in brief, 31, 105915.

Li, W., Yang, D., Zhang, Y., Zhao, S., Li, D., & Liu, M. (2020). Long non‑coding RNA PLK1S1 was associated with renal cell carcinoma progression by interacting with microRNA‑653 and altering C‑X‑C chemokine receptor 5 expression. Oncology Reports, 44(5), 1985-1996.

Ekman, I., Ihantola, E. L., Viisanen, T., Rao, D. A., Näntö-Salonen, K., Knip, M., ... & Kinnunen, T. (2019). Circulating CXCR5− PD-1hi peripheral T helper cells are associated with progression to type 1 diabetes. Diabetologia, 62(9), 1681-1688.

Hussain, M., Adah, D., Tariq, M., Lu, Y., Zhang, J., & Liu, J. (2019). CXCL13/CXCR5 signaling axis in cancer. Life sciences, 227, 175-186.

Xu, L., Liang, Z., Li, S., & Ma, J. (2018). Signaling via the CXCR5/ERK pathway is mediated by CXCL13 in mice with breast cancer. Oncology Letters, 15(6), 9293-9298.

Aqrawi, L. A., Ivanchenko, M., Björk, A., Ramírez Sepúlveda, J. I., Imgenberg-Kreuz, J., Kvarnström, M., ... & Wahren-Herlenius, M. (2018). Diminished CXCR5 expression in peripheral blood of patients with Sjögren's syndrome may relate to both genotype and salivary gland homing. Clinical & Experimental Immunology, 192(3), 259-270.

Li, R., Ma, L., Huang, H., Ou, S., Yuan, J., Xu, T., ... & Peng, X. (2017). Altered expression of CXCL13 and CXCR5 in intractable temporal lobe epilepsy patients and pilocarpine-induced epileptic rats. Neurochemical research, 42(2), 526-540.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Rat Anti-CXCR5 Recombinant Antibody (CBYY-I0027)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare