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Mouse Anti-CXCR6 Recombinant Antibody (CBXC-2718) (CBMAB-C0936-CQ)

This product is a mouse antibody that recognizes CXCR6. The antibody CBXC-2718 can be used for immunoassay techniques such as: FC, IHC-Fr, CyTOF.
See all CXCR6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-2718
Antibody Isotype
IgG2
Application
FC, IHC-Fr, CyTOF

Basic Information

Immunogen
Human CXCR6
Specificity
Human
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
C-X-C Motif Chemokine Receptor 6
Introduction
CXCR6 (C-X-C Motif Chemokine Receptor 6) is a Protein Coding gene. Diseases associated with CXCR6 include Sarcoidosis 1 and Xanthogranulomatous Cholecystitis. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-X-C chemokine receptor activity. An important paralog of this gene is CCR7.
Entrez Gene ID
UniProt ID
Alternative Names
C-X-C Motif Chemokine Receptor 6; Chemokine (C-X-C Motif) Receptor 6; G-Protein Coupled Receptor STRL33; G-Protein Coupled Receptor Bonzo; CDw186; CXC-R6; CXCR-6; STRL33;
Function
Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.
Biological Process
Calcium-mediated signaling Source: GO_Central
Cell chemotaxis Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Inflammatory response Source: InterPro
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Viral genome replication Source: ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 1-32
Helical: 33-59
Cytoplasmic: 60-68
Helical: 69-89
Extracellular: 90-103
Helical: 104-125
Cytoplasmic: 126-143
Helical: 144-164
Extracellular: 165-187
Helical: 188-215
Cytoplasmic: 216-231
Helical: 232-259
Extracellular: 260-275
Helical: 276-293
Cytoplasmic: 294-342

Li, T., Pan, J., Chen, H., Fang, Y., & Sun, Y. (2022). CXCR6-based immunotherapy in autoimmune, cancer and inflammatory infliction. Acta Pharmaceutica Sinica B.

Aguilera-Durán, G., & Romo-Mancillas, A. (2021). Behavior of Chemokine Receptor 6 (CXCR6) in Complex with CXCL16 Soluble form Chemokine by Molecular Dynamic Simulations: General Protein‒Ligand Interaction Model and 3D-QSAR Studies of Synthetic Antagonists. Life, 11(4), 346.

Han, J., Fu, R., Chen, C., Cheng, X., Guo, T., Huangfu, L., ... & Ji, J. (2021). CXCL16 Promotes Gastric Cancer Tumorigenesis via ADAM10-Dependent CXCL16/CXCR6 Axis and Activates Akt and MAPK Signaling Pathways. International journal of biological sciences, 17(11), 2841.

Lee, S. C., Lee, Y. J., Choi, I., Kim, M., & Sung, J. S. (2021). CXCL16/CXCR6 Axis in Adipocytes Differentiated from Human Adipose Derived Mesenchymal Stem Cells Regulates Macrophage Polarization. Cells, 10(12), 3410.

Godefroy, E., Alameddine, J., Montassier, E., Mathé, J., Desfrançois-Noël, J., Marec, N., ... & Altare, F. (2018). Expression of CCR6 and CXCR6 by gut-derived CD4+/CD8α+ T-regulatory cells, which are decreased in blood samples from patients with inflammatory bowel diseases. Gastroenterology, 155(4), 1205-1217.

Hong, L., Wang, S., Li, W., Wu, D., & Chen, W. (2018). Tumor-associated macrophages promote the metastasis of ovarian carcinoma cells by enhancing CXCL16/CXCR6 expression. Pathology-Research and Practice, 214(9), 1345-1351.

Adamski, V., Mentlein, R., Lucius, R., Synowitz, M., Held-Feindt, J., & Hattermann, K. (2017). The chemokine receptor CXCR6 evokes reverse signaling via the transmembrane chemokine CXCL16. International journal of molecular sciences, 18(7), 1468.

Koenen, A., Babendreyer, A., Schumacher, J., Pasqualon, T., Schwarz, N., Seifert, A., ... & Dreymueller, D. (2017). The DRF motif of CXCR6 as chemokine receptor adaptation to adhesion. PLoS One, 12(3), e0173486.

Chang, Y., Zhou, L., Xu, L., Fu, Q., Yang, Y., Lin, Z., & Xu, J. (2017, December). High expression of CXC chemokine receptor 6 associates with poor prognosis in patients with clear cell renal cell carcinoma. In Urologic Oncology: Seminars and Original Investigations (Vol. 35, No. 12, pp. 675-e17). Elsevier.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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