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Mouse Anti-CYBB Recombinant Antibody (NL7) (CBMAB-N0480-WJ)

This product is a Mouse antibody that recognizes CYBB. The antibody NL7 can be used for immunoassay techniques such as: ELISA, FC, ICC, IHC-Fr, WB.
See all CYBB antibodies
Published Data
Fig.1 The similar amount of NL7 Ab subunits bound to cytosol and LDS-activated (lane 1) and unactivated (lane 3) membranes, compared with that of an irrelevant mAb (lane 2).
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Fig.2 Concentration dependence of cytosol and NL7 on oxidase activity.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
NL7
Antibody Isotype
IgG1
Application
ELISA, FC, ICC, IHC-Fr, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.09% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CYBB
Introduction
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD).
Entrez Gene ID
1536
UniProt ID
P04839
Alternative Names
CGD; NOX2; IMD34; AMCBX2; GP91-1; GP91PHOX; p91-PHOX; GP91-PHOX
Function
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H+ currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
Biological Process
Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
Cell redox homeostasis Source: Reactome
Cellular response to cadmium ion Source: Ensembl
Cellular response to ethanol Source: Ensembl
Cellular response to L-glutamine Source: Ensembl
Cellular response to oxidative stress Source: Reactome
Defense response Source: GO_Central
Electron transport chain Source: GOC
Hypoxia-inducible factor-1alpha signaling pathway Source: Ensembl
Inflammatory response Source: UniProtKB
Innate immune response Source: BHF-UCL
Neutrophil degranulation Source: Reactome
Positive regulation of angiogenesis Source: Ensembl
Positive regulation of tumor necrosis factor production Source: Ensembl
Regulation of ion transmembrane transport Source: UniProtKB-KW
Respiratory burst Source: BHF-UCL
Response to aldosterone Source: Ensembl
Response to angiotensin Source: Ensembl
Response to drug Source: Ensembl
Response to nutrient Source: Ensembl
Superoxide anion generation Source: BHF-UCL
Superoxide metabolic process Source: BHF-UCL
Vascular endothelial growth factor receptor signaling pathway Source: Reactome
Cellular Location
Cell membrane. As unassembled monomer may localize to the endoplasmic reticulum.
Involvement in disease
Granulomatous disease, chronic, X-linked (CGD):
A form of chronic granulomatous disease, a primary immunodeficiency characterized by severe recurrent bacterial and fungal infections, along with manifestations of chronic granulomatous inflammation. It results from an impaired ability of phagocytes to mount a burst of reactive oxygen species in response to pathogens.
Immunodeficiency 34 (IMD34):
A form of Mendelian susceptibility to mycobacterial disease, a rare condition characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals.
Topology
Cytoplasmic: 2-8
Helical: 9-29
Extracellular: 30-48
Helical: 49-69
Cytoplasmic: 70-102
Helical: 103-123
Extracellular: 124-169
Helical: 170-190
Cytoplasmic: 191-200
Helical: 201-221
Extracellular: 222-261
Helical: 262-282
Cytoplasmic: 283-570
PTM
Glycosylated.
Phosphorylated on Ser and Thr residues.
Undergoes 'Lys-48'-linked polyubiquitination, likely by RNF145, triggering endoplasmic reticulum-associated degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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