Sign in or Register   Sign in or Register
  |  

Mouse Anti-CYFIP2 Recombinant Antibody (4G6) (CBMAB-C7011-LY)

This product is antibody recognizes CYFIP2. The antibody 4G6 immunoassay techniques such as: ELISA, WB.
See all CYFIP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4G6
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
CYFIP2 (NP_055191, 733 a.a. ~ 820 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: YGVIIPYPPS NRYETLLKQR HVQLLGRSID LNRLITQRIS AAMYKSLDQA ISRFESEDLT SIVELEWLLE INRLTHRLLC KHMTLDSF
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
cytoplasmic FMR1 interacting protein 2
Introduction
CYFIP2 (Cytoplasmic FMR1 Interacting Protein 2) is a Protein Coding gene. Diseases associated with CYFIP2 include Fragile X Syndrome and Amyotrophic Lateral Sclerosis 1. Among its related pathways are Innate Immune System and RET signaling. Gene Ontology (GO) annotations related to this gene include chemokine activity. An important paralog of this gene is CYFIP1.
Entrez Gene ID
26999
UniProt ID
Q96F07
Alternative Names
Cytoplasmic FMR1 Interacting Protein 2; P53-Inducible Protein 121; PIR121; Cytoplasmic FMR1-Interacting Protein 2; P53 Inducible Protein; KIAA1168;
Function
Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).
Biological Process
Activation of cysteine-type endopeptidase activity Source: BHF-UCL
Apoptotic process Source: UniProtKB
Cell-cell adhesion Source: UniProtKB
Cell morphogenesis Source: GO_Central
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
Positive regulation of proteolysis Source: BHF-UCL
Regulation of actin filament polymerization Source: InterPro
Vascular endothelial growth factor receptor signaling pathway Source: Reactome
Cellular Location
Cytoplasm; Nucleus; Perinuclear region; Synaptosome. Highly expressed in the perinuclear regionand enriched in synaptosomes (By similarity). Treatment with leptomycin-B triggers translocation to the nucleus (PubMed:17245118).
Involvement in disease
Developmental and epileptic encephalopathy 65 (DEE65):
A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE65 is an autosomal dominant form characterized by onset of intractable seizures usually in the first 6 months of life and severe to profound psychomotor developmental delay.

Manigandan, S., & Yun, J. W. (2022). Loss of cytoplasmic FMR1‐interacting protein 2 (CYFIP2) induces browning in 3T3‐L1 adipocytes via repression of GABA‐BR and activation of mTORC1. Journal of Cellular Biochemistry.

Chaya, T., Ishikane, H., Varner, L. R., Sugita, Y., Maeda, Y., Tsutsumi, R., ... & Furukawa, T. (2022). Deficiency of the neurodevelopmental disorder-associated gene Cyfip2 alters the retinal ganglion cell properties and visual acuity. Human molecular genetics, 31(4), 535-547.

Lee, Y., Zhang, Y., Kang, H., Bang, G., Kim, Y., Kang, H. R., ... & Han, K. (2020). Epilepsy-and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Biochemical and biophysical research communications, 529(1), 1-6.

Zweier, M., Begemann, A., McWalter, K., Cho, M. T., Abela, L., Banka, S., ... & Rauch, A. (2019). Spatially clustering de novo variants in CYFIP2, encoding the cytoplasmic FMRP interacting protein 2, cause intellectual disability and seizures. European Journal of Human Genetics, 27(5), 747-759.

Zhang, Y., Lee, Y., & Han, K. (2019). Neuronal function and dysfunction of CYFIP2: from actin dynamics to early infantile epileptic encephalopathy. BMB reports, 52(5), 304.

Zhang, Y., Kang, H. R., & Han, K. (2019). Differential cell-type-expression of CYFIP1 and CYFIP2 in the adult mouse hippocampus. Animal cells and systems, 23(6), 380-383.

Zhang, Y., Kang, H., Lee, Y., Kim, Y., Lee, B., Kim, J. Y., ... & Han, K. (2019). Smaller body size, early postnatal lethality, and cortical extracellular matrix-related gene expression changes of Cyfip2-null embryonic mice. Frontiers in molecular neuroscience, 11, 482.

Cioni, J. M., Wong, H. H. W., Bressan, D., Kodama, L., Harris, W. A., & Holt, C. E. (2018). Axon-axon interactions regulate topographic optic tract sorting via CYFIP2-dependent WAVE complex function. Neuron, 97(5), 1078-1093.

Kirkpatrick, S. L., Goldberg, L. R., Yazdani, N., Babbs, R. K., Wu, J., Reed, E. R., ... & Bryant, C. D. (2017). Cytoplasmic FMR1-interacting protein 2 is a major genetic factor underlying binge eating. Biological psychiatry, 81(9), 757-769.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CYFIP2 Recombinant Antibody (4G6)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare