Sign in or Register   Sign in or Register
  |  

Mouse Anti-CYP26A1 (C-terminus) Recombinant Antibody (CBFYC-2570) (CBMAB-C2644-FY)

This product is mouse antibody that recognizes CYP26A1. The antibody CBFYC-2570 can be used for immunoassay techniques such as: ELISA, IHC, WB.
See all CYP26A1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-2570
Antibody Isotype
IgG1
Application
ELISA, IHC, WB

Basic Information

Immunogen
Synthetic peptide corresponding to human CYP26A1 at C-terminal
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
C-terminus

Target

Full Name
Cytochrome P450 Family 26 Subfamily A Member 1
Introduction
CYP26A1 (Cytochrome P450 Family 26 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP26A1 include Acute Promyelocytic Leukemia and Mixed Germ Cell Cancer. Among its related pathways are Metabolism and Cytochrome P450-arranged by substrate type. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP26C1.
Entrez Gene ID
1592
UniProt ID
O43174
Alternative Names
Cytochrome P450 Family 26 Subfamily A Member 1; Cytochrome P450, Family 26, Subfamily A, Polypeptide 1; Cytochrome P450, Subfamily XXVIA, Polypeptide 1; Cytochrome P450 Retinoic Acid-Inactivating 1; Retinoic Acid-Metabolizing Cytochrome; Retinoic Acid 4-Hydroxylase; Cytochrome P450RAI; P450RAI1
Function
A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4 and C-18. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomers (PubMed:22020119, PubMed:9228017, PubMed:9716180).

May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid (PubMed:26937021).
Biological Process
Kidney development Source: Ensembl
Negative regulation of retinoic acid receptor signaling pathway Source: BHF-UCL
Response to retinoic acid Source: Ensembl
Response to vitamin A Source: Ensembl
Retinoic acid catabolic process Source: BHF-UCL
Retinoic acid metabolic process Source: UniProtKB
Sterol metabolic process Source: GO_Central
Vitamin metabolic process Source: Reactome
Xenobiotic metabolic process Source: UniProtKB
Cellular Location
Endoplasmic reticulum membrane; Microsome membrane

Horiguchi, K., Fujiwara, K., Tsukada, T., Nakakura, T., Yoshida, S., Hasegawa, R., & Takigami, S. (2022). The multiciliated cells in Rathke’s cleft express CYP26A1 and respond to retinoic acid in the pituitary. Cell and Tissue Research, 1-12.

Chen, P. H., Chung, C. M., Wang, Y. Y., Huang, H. W., Huang, B., Lee, K. W., ... & Chan, L. P. (2020). CYP26A1 is a novel biomarker for betel quid-related oral and pharyngeal cancers. Diagnostics, 10(11), 982.

Sharma, S., Liu, J., Zhang, X., Sharma, S. S., Sorensen, E. J., & Bureik, M. (2020). New luciferin-based probe substrates for human CYP26A1. Biochemistry and biophysics reports, 24, 100861.

Snyder, J. M., Zhong, G., Hogarth, C., Huang, W., Topping, T., LaFrance, J., ... & Isoherranen, N. (2020). Knockout of Cyp26a1 and Cyp26b1 during postnatal life causes reduced lifespan, dermatitis, splenomegaly, and systemic inflammation in mice. The FASEB Journal, 34(12), 15788-15804.

Guo, P., Ji, Z., Jiang, H., Huang, X., Wang, C., & Pan, B. (2020). Identification of a novel CYP26A1 mutation in a Chinese family with congenital microtia. International Journal of Pediatric Otorhinolaryngology, 139, 110488.

Zhong, G., Hogarth, C., Snyder, J. M., Palau, L., Topping, T., Huang, W., ... & Isoherranen, N. (2019). The retinoic acid hydroxylase Cyp26a1 has minor effects on postnatal vitamin A homeostasis, but is required for exogenous atRA clearance. Journal of Biological Chemistry, 294(29), 11166-11179.

Zolfaghari, R., Mattie, F. J., Wei, C. H., Chisholm, D. R., Whiting, A., & Ross, A. C. (2019). CYP26A1 gene promoter is a useful tool for reporting RAR-mediated retinoid activity. Analytical biochemistry, 577, 98-109.

Jin, L., Chang, C., Pawlik, K. M., Datta, A., Johnson, L. M., Vu, T., ... & Datta, P. K. (2018). Serine threonine kinase receptor-associated protein deficiency impairs mouse embryonic stem cells lineage commitment through CYP26A1-mediated retinoic acid homeostasis. Stem Cells, 36(9), 1368-1379.

Stevison, F., Hogarth, C., Tripathy, S., Kent, T., & Isoherranen, N. (2017). Inhibition of the all-trans retinoic acid (atRA) hydroxylases CYP26A1 and CYP26B1 results in dynamic, tissue-specific changes in endogenous atRA signaling. Drug Metabolism and Disposition, 45(7), 846-854.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CYP26A1 (C-terminus) Recombinant Antibody (CBFYC-2570)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare