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Recombinant Mouse Anti-CYP26C1 Recombinant Antibody (T6P1C7) (CBMAB-XB0308-YC)

Provided herein is a Mouse Recombinant Antibody against Cytochrome P450 Family 26 Subfamily C Member 1. The antibody can be used for immunoassay techniques, such as IHC, WB.
See all CYP26C1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
T6P1C7
Antibody Isotype
IgG1, κ
Application
IHC, WB

Basic Information

Immunogen
Ovalbumin-conjugated Synthetic peptide RWELATPAFP (C-terminal sequence)
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cytochrome P450 Family 26 Subfamily C Member 1
Introduction
CYP26C1 (Cytochrome P450 Family 26 Subfamily C Member 1) is a protein coding gene. Diseases associated with CYP26C1 include Focal Facial Dermal Dysplasia 4 and Focal Facial Dermal Dysplasia. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP26B1.
Entrez Gene ID
Human340665
Mouse546726
Rat308190
UniProt ID
HumanQ6V0L0
MouseB2RXA7
RatD4AAL3
Alternative Names
Cytochrome P450 Family 26 Subfamily C Member 1; Cytochrome P450, Family 26, Subfamily C, Polypeptide 1; Cytochrome P450 26C1; EC 1.14.-.-; FFDD4;
Function
Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate).
Biological Process
Anterior/posterior pattern specification Source: BHF-UCL
Central nervous system development Source: BHF-UCL
Negative regulation of retinoic acid receptor signaling pathway Source: BHF-UCL
Neural crest cell development Source: BHF-UCL
Organelle fusion Source: BHF-UCL
Retinoic acid catabolic process Source: BHF-UCL
Sterol metabolic process Source: GO_Central
Vitamin metabolic process Source: Reactome
Cellular Location
Membrane
Involvement in disease
Focal facial dermal dysplasia 4 (FFDD4):
A form of focal facial dermal dysplasia, a group of developmental defects characterized by bitemporal or preauricular skin lesions resembling aplasia cutis congenita. Skin defects occur at the sites of facial fusion during embryogenesis, with temporal lesions situated at the junction between the frontonasal and maxillary facial prominences, and preauricular lesions at the meeting point of the maxillary and mandibular prominences. The ectodermal lesions show consistent histologic abnormalities: atrophy and flattening of the epidermis, replacement of the dermis by loose connective tissue, reduced levels of fragmented elastic tissue and absence of the subcutaneous tissues and adnexal structures. FFDD4 is characterized by isolated, preauricular skin lesions.
Topology
Helical: 9-29
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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