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Recombinant Mouse Anti-Cyp3a1 Recombinant Antibody (P6) (CBMAB-XB0321-YC)

Provided herein is a Mouse Recombinant Antibody against Cytochrome P450, Family 3, Subfamily a, Polypeptide 23/Polypeptide 1. The antibody can be used for immunoassay techniques, such as ELISA, FC, WB.
See all Cyp3a1 antibodies

Summary

Host Animal
Mouse
Specificity
Rat, Human, Mouse
Clone
P6
Antibody Isotype
IgG1
Application
ELISA, FC, WB

Basic Information

Immunogen
Rat liver cytochrome P450 3A1
Specificity
Rat, Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cytochrome P450, Family 3, Subfamily a, Polypeptide 23/Polypeptide 1
Introduction
Cyp3a1 is a steroid-inducible member of p450 subfamily 3A and induced by pregnenolone 16 alpha-carbonitrile, dexamethasone (DEX), phenobarbital (PB) and triacetyloleandomycin.
Entrez Gene ID
25642
UniProt ID
Q06884
Alternative Names
CYP; RL33; cDEX; Cyp3a1; Cyp3a3; CYP3A23
Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Biological Process
Aging Source: RGD
Drug metabolic process Source: RGD
Oxidative demethylation Source: RGD
Response to cadmium ion Source: RGD
Response to drug Source: RGD
Response to glucocorticoid Source: RGD
Response to metal ion Source: RGD
Response to nutrient Source: RGD
Steroid metabolic process Source: GO_Central
Cellular Location
Endoplasmic reticulum membrane; Microsome membrane

Zhang, Z., Wang, Z., Li, Q. X., Hua, R., & Wu, X. (2021). Enantioselective metabolism of phenylpyrazole insecticides by rat liver microsomal CYP3A1, CYP2E1 and CYP2D2. Pesticide Biochemistry and Physiology, 176, 104861.

Hu, N., Liu, X., Mu, Q., Yu, M., Wang, H., Jiang, Y., ... & Wang, L. (2021). The gut microbiota contributes to the modulation of intestinal CYP3A1 and P-gp in streptozotocin-induced type 1 diabetic rats. European Journal of Pharmaceutical Sciences, 162, 105833.

Li, S., Li, X., Yuan, D., Wang, B., Yang, R., Zhang, M., ... & Zeng, F. (2021). Effects of paeoniflorin on the activities and mRNA expression of rat CYP1A2, CYP2C11 and CYP3A1 enzymes in vivo. Xenobiotica, 51(9), 961-967.

Xuting, L. I., Sicong, L. I., Bin, W. A. N. G., Min ZHANG, D. Y., & Jinliang, L. I. (2021). Borneol influences the pharmacokinetics of florfenicol through regulation of cytochrome P450 1A2 (CYP1A2), CYP2C11, CYP3A1, and multidrug resistance 1 (MDR1) mRNA expression levels in rats. The Journal of Veterinary Medical Science, 83(8), 1338.

Li, X., Li, S., Wang, B., Zhang, M., Yuan, D., Li, J., & Liang, G. (2021). Borneol influences the pharmacokinetics of florfenicol through regulation of cytochrome P450 1A2 (CYP1A2), CYP2C11, CYP3A1, and multidrug resistance 1 (MDR1) mRNA expression levels in rats. Journal of Veterinary Medical Science, 83(8), 1338-1344.

Li, S. C., Li, X. T., Wang, B., Yang, R., Zhang, M., Li, J. L., ... & Xiao, S. Y. (2020). Effects of baicalin on pharmacokinetics of florfenicol and mRNA expression of CYP1A2, CYP2C11, CYP3A1, UGT1A1, MDR1, and ABCC2 in rats. Pharmacognosy Magazine, 16(67), 1.

Gong, W., Xu, P., Guo, S., Li, X., Jin, Z., Zhao, Y., ... & Xue, M. (2017). Effect of hypoxia on the pharmacokinetics and metabolism of zaleplon as a probe of CYP3A1/2 activity. RSC advances, 7(41), 25414-25421.

Athukuri, B. L., & Neerati, P. (2017). Enhanced oral bioavailability of domperidone with piperine in male wistar rats: involvement of CYP3A1 and P-gp inhibition. Journal of Pharmacy & Pharmaceutical Sciences, 20, 28-37.

Abdelhadya, D. H., El-Magd, M. A., Elbialy, Z. I., & Saleh, A. A. (2017). Bromuconazole-induced hepatotoxicity is accompanied by upregulation of PXR/CYP3A1 and downregulation of CAR/CYP2B1 gene expression. Toxicology Mechanisms and Methods, 27(7), 544-550.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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