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Rabbit Anti-CCN1 Recombinant Antibody (CBWJC-3580) (CBMAB-C4816WJ)

This product is a Rabbit antibody that recognizes CYR61. This antibody CBWJC-3580 can be used for immunoassay techniques such as: WB, IF, FC.
See all CCN1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBWJC-3580
Antibody Isotype
IgG
Application
WB, IF, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CCN1
Introduction
CYR61 (Cysteine Rich Angiogenic Inducer 61) is a Protein Coding gene. Diseases associated with CYR61 include Arthropathy, Progressive Pseudorheumatoid, Of Childhood and Epispadias. Among its related pathways are RhoA signaling pathway and Hypertrophy Model. Gene Ontology (GO) annotations related to this gene include heparin binding and extracellular matrix binding. An important paralog of this gene is CTGF.
Entrez Gene ID
3491
UniProt ID
O00622
Alternative Names
Cysteine Rich Angiogenic Inducer 61; Insulin-Like Growth Factor-Binding Protein 10; IGF-Binding Protein 10; CCN Family Member 1; IGFBP-10; IGFBP10; IBP-10; CCN1;
Function
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
Biological Process
Apoptotic process involved in heart morphogenesis Source: Ensembl
Atrial septum morphogenesis Source: Ensembl
Atrioventricular valve morphogenesis Source: Ensembl
Cell adhesion Source: GO_Central
Cellular protein metabolic process Source: Reactome
Chemotaxis Source: UniProtKB-KW
Chondroblast differentiation Source: Ensembl
Chorio-allantoic fusion Source: Ensembl
Extracellular matrix organization Source: Ensembl
Intussusceptive angiogenesis Source: Ensembl
Labyrinthine layer blood vessel development Source: Ensembl
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of cell death Source: GO_Central
Osteoblast differentiation Source: Ensembl
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of BMP signaling pathway Source: BHF-UCL
Positive regulation of bone mineralization Source: BHF-UCL
Positive regulation of cartilage development Source: Ensembl
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of cell-substrate adhesion Source: Ensembl
Positive regulation of ceramide biosynthetic process Source: Ensembl
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
Positive regulation of osteoblast differentiation Source: BHF-UCL
Positive regulation of osteoblast proliferation Source: BHF-UCL
Positive regulation of phospholipase activity Source: Ensembl
Positive regulation of protein kinase activity Source: BHF-UCL
Positive regulation of protein phosphorylation Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Post-translational protein modification Source: Reactome
Reactive oxygen species metabolic process Source: Ensembl
Regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Signal transduction Source: GO_Central
Ventricular septum development Source: Ensembl
Wound healing, spreading of cells Source: BHF-UCL
Cellular Location
Secreted

Liu, H., Li, J., Jiang, C., Yuan, T., & Ma, H. (2021). Cellular Communication Network Factor 1 (CCN1) Knockdown Exerts a Protective Effect for Hepatic Ischemia/Reperfusion Injury by Deactivating the MEK/ERK Pathway. Clinics and Research in Hepatology and Gastroenterology, 101737.

Bartkowiak, K., Heidrich, I., Kwiatkowski, M., Banys-Paluchowski, M., Andreas, A., Wurlitzer, M., ... & Pantel, K. (2021). Circulating Cellular Communication Network Factor 1 Protein as a Sensitive Liquid Biopsy Marker for Early Detection of Breast Cancer. Clinical Chemistry.

Esaily, H. A., Serag, D. M., Rizk, M. S., Badr, I. T., Sonbol, A. A., & Fotoh, D. S. (2021). Relationship between cellular communication network factor 1 (CCN1) and carotid atherosclerosis in patients with rheumatoid arthritis. The Medical journal of Malaysia, 76(3), 311-317.

Li, Y., Fan, S., Xia, W., Qiao, B., Huang, K., Zhou, J., & Liang, M. (2021). MiR-181b suppresses angiogenesis by directly targeting cellular communication network factor 1. Laboratory Investigation, 1-10.

Monie, D. D., Correia, C., Zhang, C., Ung, C. Y., Vile, R. G., & Li, H. (2021). Modular network mechanism of CCN1-associated resistance to HSV-1-derived oncolytic immunovirotherapies for glioblastomas. Scientific reports, 11(1), 1-12.

Feng, M., Peng, H., Yao, R., Zhang, Z., Mao, G., Yu, H., & Qiu, Y. (2020). Inhibition of cellular communication network factor 1 (CCN1)-driven senescence slows down cartilage inflammaging and osteoarthritis. Bone, 139, 115522.

Piet, S. (2020). Regulation of Cellular Communication Network Factor 1 (CCN1) by Signal Transducer and Activator of Transcription 3 (STAT3) and Calcium in Ovarian Adenocarcinoma (OVCAR8) Cells.

Palin, A., Piet, S., Elder, D., & Tsang, P. (2020). Effects of Fetal Bovine Serum (FBS) Concentration on mRNA Expression of Cellular Communication Network Factor 1 (CCN1) in Bovine Granulosa Cells.

Lee, S., Ahad, A., Luu, M., Moon, S., Caesar, J., Cardoso, W. V., ... & Chaqour, B. (2019). CCN1–Yes-associated protein feedback loop regulates physiological and pathological angiogenesis. Molecular and cellular biology, 39(18), e00107-19.

Perbal, B., Tweedie, S., & Bruford, E. (2018). The official unified nomenclature adopted by the HGNC calls for the use of the acronyms, CCN1–6, and discontinuation in the use of CYR61, CTGF, NOV and WISP 1–3 respectively.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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