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Mouse Anti-DAK Recombinant Antibody (1D9) (CBMAB-A2077-LY)

The product is antibody recognizes DAK. The antibody 1D9 immunoassay techniques such as: sELISA, ELISA.
See all DAK antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D9
Antibody Isotype
IgG2a, κ
Application
sELISA, ELISA

Basic Information

Immunogen
DAK (AAH01341, 1 a.a. ~ 575 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
Introduction
This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been identified, but the full-length nature of only one has been determined. [provided by RefSeq]
Entrez Gene ID
26007
Alternative Names
DKFZp586B1621; MGC5621
Function
Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response (PubMed:17600090).
Biological Process
Carbohydrate phosphorylation Source: UniProtKB
Cellular carbohydrate metabolic process Source: UniProtKB
Fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate Source: Reactome
Glycerol catabolic process Source: GO_Central
Innate immune response Source: Reactome
Negative regulation of MDA-5 signaling pathway Source: UniProtKB
Regulation of innate immune response Source: UniProtKB
Cellular Location
Cytosol; Extracellular exosome; Nucleus
Involvement in disease
Triokinase and FMN cyclase deficiency syndrome (TKFCD):
An autosomal recessive disease characterized by cataracts and developmental delay that may be associated with cerebellar hypoplasia. Additional features may include liver dysfunction, microcytic anemia, and fatal cardiomyopathy with lactic acidosis following a febrile illness.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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