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Mouse Anti-DKK1 Recombinant Antibody (CBXS-0968) (CBMAB-S3877-CQ)

This product is a mouse antibody that recognizes DKK1. The antibody CBXS-0968 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-Fr, ELISA.
See all DKK1 antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBXS-0968
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Dickkopf Related Protein 1
Specificity
Rat
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dickkopf WNT Signaling Pathway Inhibitor 1
Introduction
This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
Entrez Gene ID
293897
UniProt ID
D3Z9J1
Alternative Names
DKK-1; SK
Function
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856).

DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291).

Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).
Biological Process
Learning or memory Source: ARUK-UCL
Limb development Source: UniProtKB
Modulation of age-related behavioral decline Source: ARUK-UCL
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment Source: BHF-UCL
Negative regulation of cardiac muscle cell differentiation Source: BHF-UCL
Negative regulation of mesodermal cell fate specification Source: BHF-UCL
Negative regulation of ossification Source: UniProtKB
Negative regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
Negative regulation of peptidyl-serine phosphorylation Source: BHF-UCL
Negative regulation of protein binding Source: ParkinsonsUK-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Negative regulation of Wnt-Frizzled-LRP5/6 complex assembly Source: ParkinsonsUK-UCL
Negative regulation of Wnt signaling pathway Source: UniProtKB
Positive regulation of cell death Source: ARUK-UCL
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
Positive regulation of JUN kinase activity Source: ARUK-UCL
Positive regulation of neuron death Source: ARUK-UCL
Positive regulation of tau-protein kinase activity Source: ARUK-UCL
Positive regulation of Wnt signaling pathway, calcium modulating pathway Source: ARUK-UCL
Positive regulation of Wnt signaling pathway, planar cell polarity pathway Source: ARUK-UCL
Regulation of dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
Regulation of endodermal cell fate specification Source: BHF-UCL
Regulation of receptor internalization Source: BHF-UCL
Synapse pruning Source: ParkinsonsUK-UCL
Wnt signaling pathway Source: UniProtKB-KW
Cellular Location
Secreted

Zhu, G., Song, J., Chen, W., Yuan, D., Wang, W., Chen, X., ... & Zhu, J. (2021). Expression and role of Dickkopf-1 (Dkk1) in tumors: from the cells to the patients. Cancer Management and Research, 13, 659.

Supsavhad, W., Hassan, B. B., Simmons, J. K., Dirksen, W. P., Elshafae, S. M., Kohart, N. A., ... & Rosol, T. J. (2021). Effect of Dickkopf-1 (Dkk-1) and SP600125, a JNK Inhibitor, on Wnt Signaling in Canine Prostate Cancer Growth and Bone Metastases. Veterinary sciences, 8(8), 153.

Bahie, A., Abdalbary, M. M., El-Sayed, D. Y., Elzehery, R., El-Said, G., El-Kannishy, G., & Abd El Wahab, A. M. (2021). Relation of Wnt Signaling Pathway Inhibitors (Sclerostin and Dickkopf-1) to Left Ventricular Mass Index in Maintenance Hemodialysis Patients. International Journal of Nephrology, 2021.

Jaschke, N., Hofbauer, L. C., Göbel, A., & Rachner, T. D. (2020). Evolving functions of Dickkopf-1 in cancer and immunity. Cancer letters, 482, 1-7.

Jia, Y., Chen, L., Guo, S., & Li, Y. (2019). Baicalin induced colon cancer cells apoptosis through miR-217/DKK1-mediated inhibition of Wnt signaling pathway. Molecular biology reports, 46(2), 1693-1700.

Singh, A., Gupta, M. K., & Mishra, S. P. (2019). Study of correlation of level of expression of Wnt signaling pathway inhibitors sclerostin and dickkopf-1 with disease activity and severity in rheumatoid arthritis patients. Drug Discoveries & Therapeutics, 13(1), 22-27.

Lyros, O., Lamprecht, A. K., Nie, L., Thieme, R., Götzel, K., Gasparri, M., ... & Gockel, I. (2019). Dickkopf-1 (DKK1) promotes tumor growth via Akt-phosphorylation and independently of Wnt-axis in Barrett’s associated esophageal adenocarcinoma. American journal of cancer research, 9(2), 330.

Huang, Y., Liu, L., & Liu, A. (2018). Dickkopf-1: current knowledge and related diseases. Life sciences, 209, 249-254.

Kasoha, M., Bohle, R. M., Seibold, A., Gerlinger, C., Juhasz-Boess, I., & Solomayer, E. F. (2018). Dickkopf-1 (Dkk1) protein expression in breast cancer with special reference to bone metastases. Clinical & experimental metastasis, 35(8), 763-775.

Kagey, M. H., & He, X. (2017). Rationale for targeting the Wnt signalling modulator Dickkopf‐1 for oncology. British journal of pharmacology, 174(24), 4637-4650.

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For research use only. Not intended for any clinical use.

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