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Rabbit Anti-DMGDH Monoclonal Antibody (EPR16908) (CBMAB-1034-YC)

Provided herein is a rabbit monoclonal antibody against Human DMGDH. The antibody, clone EPR16908, can be used for immunoassay techniques, such as IHC-P, IP and WB.
See all DMGDH antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EPR16908
Antibody Isotype
IgG
Application
IHC-P, IP, WB

Basic Information

Immunogen
Synthetic peptide within Human DMGDH aa 850 to the C-terminus.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dimethylglycine Dehydrogenase
Introduction
Dimethylglycine dehydrogenase (DMGDH) catalyzes the oxidative demethylation of dimethylglycine to form sarcosine, which is involved in the catabolism of choline. Mutation in DMGDH causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum.
Entrez Gene ID
UniProt ID
Alternative Names
DMGDHD; ME2GLYDH
Function
Catalyzes the demethylation of N,N-dimethylglycine to sarcosine. Also has activity with sarcosine in vitro.
Biological Process
Amino-acid betaine catabolic process Source: UniProtKB-UniPathway
Choline catabolic process Source: UniProtKB
Choline metabolic process Source: UniProtKB
Cellular Location
Mitochondrion
Involvement in disease
DMGDH deficiency (DMGDHD):
Disorder characterized by fish odor, muscle fatigue with increased serum creatine kinase. Biochemically it is characterized by an increase of N,N-dimethylglycine (DMG) in serum and urine.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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