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Mouse Anti-DNAAF4 Monoclonal Antibody (6G1) (CBMAB-1108-YC)

Provided herein is a mouse monoclonal antibody against Human DNAAF4. The antibody, clone 6G1, can be used for immunoassay techniques, such as ELISA, IF, IP and WB.
See all DNAAF4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6G1
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, IP, WB

Basic Information

Immunogen
Partial recombinant protein DYX1C1 (NP_570722, aa 336-420) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
Located in aa 336-420, partial

Target

Full Name
Dynein Axonemal Assembly Factor 4
Introduction
DNAAF4 is a tetratricopeptide repeat domain-containing protein, which interacts with estrogen receptors and the heat shock proteins, Hsp70 and Hsp90. Mutations in this gene are associated with deficits in reading and spelling.
Entrez Gene ID
161582
UniProt ID
Q8WXU2
Alternative Names
RD; DYX1; EKN1; DYXC1; CILD25; DYX1C1
Function
Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity.
Biological Process
Cilium movement Source: UniProtKB
Determination of left/right symmetry Source: UniProtKB
Epithelial cilium movement involved in extracellular fluid movement Source: GO_Central
Heart development Source: GO_Central
Inner dynein arm assembly Source: UniProtKB
Neuron migration Source: UniProtKB
Outer dynein arm assembly Source: UniProtKB
Regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
Regulation of proteasomal protein catabolic process Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm; Dynein axonemal particle; Neuron projection
Involvement in disease
Dyslexia 1 (DYX1):
Disease susceptibility is associated with variants affecting the gene represented in this entry. A chromosomal aberration involving DNAAF4 has been found in a family affected by dyslexia. Translocation t(2;15)(q11;q21). A relatively common, complex cognitive disorder characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities. It is a multifactorial trait, with evidence for familial clustering and heritability.
Ciliary dyskinesia, primary, 25 (CILD25):
A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Patients may exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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