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Mouse Anti-DPP9 Recombinant Antibody (2E3) (CBMAB-D1614-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dipeptidyl Peptidase 9 (DPP9). The antibody can be used for immunoassay techniques, such as FC, IHC, WB.
See all DPP9 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2E3
Antibody Isotype
IgG1
Application
FC, IHC, WB

Basic Information

Immunogen
A full length recombinant protein of human DPP9 (NP_631898) produced in HEK293T cells
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dipeptidyl Peptidase 9
Introduction
DPP9 is a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized.
Entrez Gene ID
91039
UniProt ID
Q86TI2
Alternative Names
Dipeptidyl Peptidase 9; Dipeptidyl Peptidase-Like Protein 9; Dipeptidyl Peptidase IX; Dipeptidylpeptidase 9; DPP IX; DPRP-2; DPLP9;
Function
Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:12662155, PubMed:16475979, PubMed:19667070, PubMed:30291141, PubMed:29382749).

Acts as an inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis: inhibits pyroptosis by preventing activation of NLRP1 and CARD8 via an unknown mechanism (PubMed:27820798, PubMed:30291141, PubMed:29967349, PubMed:31525884, PubMed:32796818).
Cellular Location
Isoform 1: Cytosol
Isoform 2: Nucleus

Silva-Garcia, M., Bolgi, O., Ross, B., Pilla, E., Kari, V., Killisch, M., ... & Geiss-Friedlander, R. (2020). Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair. bioRxiv.

Wu, Q. Q., Zhao, M., Huang, G. Z., Zheng, Z. N., Chen, Y., Zeng, W. S., & Lv, X. Z. (2020). Fibroblast activation protein (FAP) overexpression induces epithelial–mesenchymal transition (EMT) in oral squamous cell carcinoma by down-regulating dipeptidyl peptidase 9 (DPP9). OncoTargets and therapy, 13, 2599.

Saso, K., Miyoshi, N., Fujino, S., Sasaki, M., Yasui, M., Ohue, M., ... & Eguchi, H. (2020). Dipeptidyl Peptidase 9 Increases Chemoresistance and is an Indicator of Poor Prognosis in Colorectal Cancer. Annals of Surgical Oncology, 27(11), 4337-4347.

Brunetti, M., Holth, A., Panagopoulos, I., Staff, A. C., Micci, F., & Davidson, B. (2019). Expression and clinical role of the dipeptidyl peptidases DPP8 and DPP9 in ovarian carcinoma. Virchows Archiv, 474(2), 177-185.

Zhong, F. L., Robinson, K., Teo, D. E. T., Tan, K. Y., Lim, C., Harapas, C. R., ... & Reversade, B. (2018). Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding. Journal of Biological Chemistry, 293(49), 18864-18878.

Ross, B., Krapp, S., Augustin, M., Kierfersauer, R., Arciniega, M., Geiss-Friedlander, R., & Huber, R. (2018). Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer. Proceedings of the National Academy of Sciences, 115(7), E1437-E1445.

Gabrilovac, J., Čupić, B., Zapletal, E., Kraus, O., & Jakić-Razumović, J. (2017). Dipeptidyl peptidase 9 (DPP9) in human skin cells. Immunobiology, 222(2), 327-342.

Tang, Z., Li, J., Shen, Q., Feng, J., Liu, H., Wang, W., ... & Ni, S. (2017). Contribution of upregulated dipeptidyl peptidase 9 (DPP9) in promoting tumoregenicity, metastasis and the prediction of poor prognosis in non‐small cell lung cancer (NSCLC). International Journal of Cancer, 140(7), 1620-1632.

Zapletal, E., Cupic, B., & Gabrilovac, J. (2017). Expression, subcellular localisation, and possible roles of dipeptidyl peptidase 9 (DPP9) in murine macrophages. Cell Biochemistry and Function, 35(2), 124-137.

Gall, M. G., & Gorrell, M. D. (2017). The multifunctional post-proline dipeptidyl peptidase, DPP9, in mice, cell biology and immunity. In Pathophysiological aspects of proteases (pp. 23-45). Springer, Singapore.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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