Sign in or Register   Sign in or Register
  |  

Mouse Anti-DYRK1A Recombinant Antibody (7D10) (CBMAB-D2014-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all DYRK1A antibodies
Published Data

Summary

Host Animal
Mouse
Specificity
Human
Clone
7D10
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A
Introduction
DYRK1A belongs to the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.
Entrez Gene ID
UniProt ID
Alternative Names
Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A; Dual Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1A; Dual Specificity YAK1-Related Kinase; Protein Kinase Minibrain Homolog; DYRK; MNBH; HP86; MNB; Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1A; Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A;
Research Area
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity).

Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity).
Biological Process
Amyloid-beta formation Source: ARUK-UCL
Circadian rhythm Source: UniProtKB
Negative regulation of DNA damage response, signal transduction by p53 class mediator Source: BHF-UCL
Negative regulation of microtubule polymerization Source: ARUK-UCL
Negative regulation of mRNA splicing, via spliceosome Source: Ensembl
Nervous system development Source: ProtInc
Peptidyl-serine autophosphorylation Source: ARUK-UCL
Peptidyl-serine phosphorylation Source: ARUK-UCL
Peptidyl-threonine phosphorylation Source: BHF-UCL
Peptidyl-tyrosine autophosphorylation Source: ARUK-UCL
Peptidyl-tyrosine phosphorylation Source: MGI
Positive regulation of protein deacetylation Source: BHF-UCL
Positive regulation of RNA splicing Source: ARUK-UCL
Positive regulation of transcription, DNA-templated Source: GO_Central
Protein autophosphorylation Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Regulation of alternative mRNA splicing, via spliceosome Source: Ensembl
Cellular Location
Nucleus; Nucleus speckle
Involvement in disease
Mental retardation, autosomal dominant 7 (MRD7):
A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
PTM
Autophosphorylated on numerous tyrosine residues. Can also autophosphorylate on serine and threonine residues (in vitro).

Bessone, I. F., Navarro, J., Martinez, E., Karmirian, K., Holubiec, M., Alloatti, M., ... & Falzone, T. L. (2022). DYRK1A regulates the bidirectional axonal transport of APP in human-derived neurons. Journal of Neuroscience, 42(33), 6344-6358.

Weber, C., Sipos, M., Paczal, A., Balint, B., Kun, V., Foloppe, N., ... & Kotschy, A. (2021). Structure-guided discovery of potent and selective DYRK1A inhibitors. Journal of Medicinal Chemistry, 64(10), 6745-6764.

Demuro, S., Di Martino, R. M., Ortega, J. A., & Cavalli, A. (2021). GSK-3β, FYN, and DYRK1A: master regulators in neurodegenerative pathways. International Journal of Molecular Sciences, 22(16), 9098.

Laham, A. J., Saber-Ayad, M., & El-Awady, R. (2021). DYRK1A: A down syndrome-related dual protein kinase with a versatile role in tumorigenesis. Cellular and Molecular Life Sciences, 78(2), 603-619.

Bhansali, R. S., Rammohan, M., Lee, P., Laurent, A. P., Wen, Q., Suraneni, P., ... & Crispino, J. D. (2021). DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3. The Journal of clinical investigation, 131(1).

Lee Walmsley, D., Murray, J. B., Dokurno, P., Massey, A. J., Benwell, K., Fiumana, A., ... & Hubbard, R. E. (2021). Fragment-derived selective inhibitors of dual-specificity kinases DYRK1A and DYRK1B. Journal of Medicinal Chemistry, 64(13), 8971-8991.

Walter, C., Marada, A., Suhm, T., Ernsberger, R., Muders, V., Kücükköse, C., ... & Meisinger, C. (2021). Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery. Nature communications, 12(1), 1-12.

Kumar, K., Suebsuwong, C., Wang, P., Garcia-Ocana, A., Stewart, A. F., & DeVita, R. J. (2021). DYRK1A inhibitors as potential therapeutics for β-cell regeneration for diabetes. Journal of Medicinal Chemistry, 64(6), 2901-2922.

Recasens, A., Humphrey, S. J., Ellis, M., Hoque, M., Abbassi, R. H., Chen, B., ... & Munoz, L. (2021). Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells. Cell death discovery, 7(1), 1-16.

Arbones, M. L., Thomazeau, A., Nakano-Kobayashi, A., Hagiwara, M., & Delabar, J. M. (2019). DYRK1A and cognition: A lifelong relationship. Pharmacology & therapeutics, 194, 199-221.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Mouse Anti-DYRK1A Recombinant Antibody (7D10)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare