Sign in or Register   Sign in or Register
  |  

Rat Anti-EBI3 Recombinant Antibody (5P10D3) (CBMAB-I1489-YY)

This product is Rat antibody that recognizes EBI3. The antibody 5P10D3 can be used for immunoassay techniques such as: WB, FC
See all EBI3 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
5P10D3
Antibody Isotype
IgG2b, κ
Application
WB, FC

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Epstein-Barr virus induced 3
Introduction
This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27).
Entrez Gene ID
UniProt ID
Alternative Names
EBI-3; IL-27
Research Area
Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
Biological Process
Cytokine-mediated signaling pathway Source: GO_Central
Humoral immune response Source: ProtInc
Leptin-mediated signaling pathway Source: GO_Central
Positive regulation of alpha-beta T cell proliferation Source: UniProtKB
Positive regulation of interferon-gamma production Source: UniProtKB
T-helper 1 type immune response Source: UniProtKB
Cellular Location
Secreted

Yonekura, S. (2022). Epstein-Barr Virus-induced Gene 3 as a Novel Biomarker in Metastatic Melanoma With Infiltrating CD8+ T Cells: A Study Based on The Cancer Genome Atlas (TCGA). Anticancer Research, 42(1), 511-517.

Sawada, L., Vallinoto, A. C. R., & Brasil-Costa, I. (2021). Regulation of the Immune Checkpoint Indoleamine 2, 3-Dioxygenase Expression by Epstein–Barr Virus. Biomolecules, 11(12), 1792.

Posadas-Sánchez, R., del Carmen González-Salazar, M., Cardoso-Saldaña, G., Criales-Vera, S. A., Reyes-Barrera, J., Pérez-Hernández, N., ... & Vargas-Alarcón, G. (2020). Epstein-Barr virus-induced gene 3 (EBI3) single nucleotide polymorphisms and their association with central obesity and risk factors for cardiovascular disease: the GEA study. Cytokine, 135, 155225.

Jeon, J., Lee, Y., Yu, H., & Ha, U. H. (2020). HSP70-homolog DnaK of Pseudomonas aeruginosa increases the production of IL-27 through expression of EBI3 via TLR4-dependent NF-κB and TLR4-independent Akt signaling. International Journal of Molecular Sciences, 21(23), 9194.

Iranshahi, N., Assar, S., Amiri, S. M., Zafari, P., Fekri, A., & Taghadosi, M. (2019). Decreased gene expression of Epstein–Barr Virus-Induced Gene 3 (EBI-3) may contribute to the pathogenesis of rheumatoid arthritis. Immunological investigations, 48(4), 367-377.

Deng, J. H., Chen, H. Y., Huang, C., Yan, J. M., Yin, Z., Zhang, X. L., & Pan, Q. (2019). Accumulation of EBI3 induced by virulent Mycobacterium tuberculosis inhibits apoptosis in murine macrophages. Pathogens and disease, 77(1), ftz007.

Chu, J. H., Yan, X., Liang, A., Hu, B., Gomez, J. L., & Chupp, G. L. (2019). Integration of Sputum eQTL and GWAS Indicates IL-27/EBI3 Pathway Is Associated with Severe Asthma. In D29. LUNG MULTI-OMICS TO MECHANISM (pp. A6088-A6088). American Thoracic Society.

Zheng, H., & Huang, J. (2018). Prognostic Value of Epstein-Barr Virus (EBV)-Induced Gene 3 (EBI3) in Diffuse Large B Cell Lymphoma. Blood, 132, 5411.

Song, Q., Chen, X., Hu, W., Mei, G., Yang, X., & Wu, H. (2018). Downregulation of Epstein-Barr virus-induced gene 3 is associated with poor prognosis of hepatocellular carcinoma after curative resection. Oncology Letters, 15(5), 7751-7759.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Rat Anti-EBI3 Recombinant Antibody (5P10D3)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare