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Recombinant Mouse Anti-Ebola Virus Nucleoprotein Antibody (CB3153) (CBMAB-MD1257-LY)

The product is antibody recognizes Ebola Virus. The antibody CB3153 immunoassay techniques such as: ELISA, WB.
See all Ebola Virus Nucleoprotein antibodies

Summary

Host Animal
Mouse
Specificity
Ebola Virus
Clone
CB3153
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Recombinant Ebola Virus nucleoprotein.
Specificity
Ebola Virus
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.1% Sodium Azide
Purity
> 90% Purity determined by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Ebola Virus Nucleoprotein
Research Area
Oligomerizes into helical capsid to encapsidate the viral genome, protecting it from nucleases and the cellular innate immune response (PubMed:26119732, PubMed:25865894, PubMed:30333622, PubMed:16719918).

VP35 binds to and stabilizes monomeric NP, keeping it soluble (PubMed:26119732, PubMed:25865894).

Upon virus replication, NP is recruited to bind cooperatively viral genomic RNA and VP35 is released (PubMed:29144446).

The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. The nucleocapsid is helical with a pitch of 10.81 NP per turn and a diameter of about 22nm (PubMed:22247782).

Each NP binds to six nucleotides of viral genomic RNA, three being exposed to the solvant and three hidden into the nucleocapsid (PubMed:30333622).

Recruits also host PPP2R5C phosphatase to dephosphorylate VP30 and thereby promote viral transcription (PubMed:29290611, PubMed:27755595).

Upon virion assembly and budding, NP binds to VP24 and possibly host STAU1 (PubMed:28794491, PubMed:30301857).
Biological Process
Viral RNA genome packaging Source: InterPro
PTM
Phosphorylated by host.
O-glycosylated by host.
Acetylated by host EP300 in vitro.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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