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Mouse Anti-ECR Recombinant Antibody (15G1a) (CBMAB-0039-CN)

This product is a mouse antibody that recognizes ECR of Drosophila. The antibody 15G1a can be used for immunoassay techniques such as: IHC, WB.
See all ECR antibodies

Summary

Host Animal
Mouse
Specificity
Common fruit fly
Clone
15G1a
Antibody Isotype
IgG1, κ
Application
IHC, WB

Basic Information

Immunogen
Amino acids 15-152 of EcR-A.
Specificity
Common fruit fly
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
EcR
Introduction
Ecdysone receptor (EcR) interacts with usp to form the nuclear ecdysone receptor heterodimer, which modulates, in conjunction with co-activators and co-repressors, the activities of hundreds of genes in a tissue- and stage-specific way. EcR is widely expressed in embryonic and larval tissues and in some adult tissues where its activities (modulated by the hormone ecdysone) trigger both molting and metamorphosis. This protein binds to ecdysone response elements (ECRES) following ecdysone-binding, and recruitment of a complex containing the histone methyltransferase trr, leads to activate transcription of target genes.
Entrez Gene ID
35540
UniProt ID
P34021
Alternative Names
anon-WO0229075.1; CG1765; CG8347; dECR; DEcR; Dhr23; dmEcR; DmEcR; Dmel\CG1765; EcdR; ecr; Ecr; ECR; EcR-A; EcR-B; EcR-B1; ECR-C; Ecr1B; EcR1b; EcRA; EcRB; EcRB-1; EcRB1; EcRC; lie; ms(2)06410; ms(2)42A; NR1H1; snt
Biological Process
Ecdysone receptor-mediated signaling pathway Source: InterPro
Cellular Location
Nucleus

Maharaj, S., Ekoka, E., Erlank, E., Nardini, L., Reader, J., Birkholtz, L. M., & Koekemoer, L. L. (2022). The ecdysone receptor regulates several key physiological factors in Anopheles funestus. Malaria journal, 21(1), 1-13.

Wu, J. J., Mu, L. L., Kang, W. N., Ze, L. J., Shen, C. H., Jin, L., ... & Li, G. Q. (2021). RNA interference targeting ecdysone receptor blocks the larval–pupal transition in Henosepilachna vigintioctopunctata. Insect science, 28(2), 419-429.

He, Y. Z., Aksoy, E., Ding, Y., & Raikhel, A. S. (2021). Hormone-dependent activation and repression of microRNAs by the ecdysone receptor in the dengue vector mosquito Aedes aegypti. Proceedings of the National Academy of Sciences, 118(26), e2102417118.

Abdullah‐Zawawi, M. R., Afiqah‐Aleng, N., Ikhwanuddin, M., Sung, Y. Y., Tola, S., Fazhan, H., & Waiho, K. (2021). Recent development in ecdysone receptor of crustaceans: current knowledge and future applications in crustacean aquaculture. Reviews in Aquaculture, 13(4), 1938-1957.

Yogindran, S., & Rajam, M. V. (2021). Host-derived artificial miRNA-mediated silencing of ecdysone receptor gene provides enhanced resistance to Helicoverpa armigera in tomato. Genomics, 113(1), 736-747.

Petruccelli, E., Lark, A., Mrkvicka, J. A., & Kitamoto, T. (2020). Significance of DopEcR, a G-protein coupled dopamine/ecdysteroid receptor, in physiological and behavioral response to stressors. Journal of neurogenetics, 34(1), 55-68.

Li, X., Ren, X., Liu, Y., Smagghe, G., Liang, P., & Gao, X. (2020). MiR-189942 regulates fufenozide susceptibility by modulating ecdysone receptor isoform B in Plutella xylostella (L.). Pesticide biochemistry and physiology, 163, 235-240.

Mellor, C. L., Tollefsen, K. E., LaLone, C., Cronin, M. T., & Firman, J. W. (2020). In silico identification of chemicals capable of binding to the ecdysone receptor. Environmental toxicology and chemistry, 39(7), 1438-1450.

Chan, Y. H., Chu, K. H., & Chan, K. M. (2019). Ecdysteroid-mimicking compounds act as both agonists and antagonists to the crustacean ecdysone receptor. Chemosphere, 237, 124551.

Lenaerts, C., Marchal, E., Peeters, P., & Vanden Broeck, J. (2019). The ecdysone receptor complex is essential for the reproductive success in the female desert locust, Schistocerca gregaria. Scientific reports, 9(1), 1-12.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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