Mouse Anti-ELAVL3 Recombinant Antibody (CBFYE-0764) (CBMAB-E1208-FY)

This product is mouse antibody that recognizes ELAVL3. The antibody CBFYE-0764 can be used for immunoassay techniques such as: IF, WB.
See all ELAVL3 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYE-0764

Antibody Isotype

IgG2b, κ

Application

IF, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Elav Like Rna Binding Protein 3

Introduction

A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Entrez Gene ID

1995

UniProt ID

Q14576

Alternative Names

ELAV Like RNA Binding Protein 3; Paraneoplastic Cerebellar Degeneration-Associated Antigen; Paraneoplastic Limbic Encephalitis Antigen 21; ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 3 (Hu Antigen C); ELAV Like Neuron-Specific RNA Binding Protein 3; ELAV-Like Protein 3

Research Area

RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA (PubMed:10710437).

May also bind poly-A tracts via RRM 3 (By similarity).

May be involved in neuronal differentiation and maintenance (By similarity).

Plays a role in the stabilization of GAP43 mRNA and in spatial learning (By similarity).

Biological Process

Cell differentiation Source: UniProtKB-KW
Nervous system development Source: UniProtKB-KW

Cellular Location

Ribonucleoprotein complex

References

Lu, Y. L., Liu, Y., McCoy, M. J., & Yoo, A. S. (2021). MiR-124 synergism with ELAVL3 enhances target gene expression to promote neuronal maturity. Proceedings of the National Academy of Sciences, 118(22), e2015454118.

Diaz-Garcia, S., Ko, V. I., Vazquez-Sanchez, S., Chia, R., Arogundade, O. A., Rodriguez, M. J., ... & Ravits, J. (2021). Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis. Acta neuropathologica, 142(6), 985-1001.

Grassi, E., Santoro, R., Umbach, A., Grosso, A., Oliviero, S., Neri, F., ... & Merlo, G. R. (2019). Choice of alternative polyadenylation sites, mediated by the RNA-binding protein Elavl3, plays a role in differentiation of inhibitory neuronal progenitors. Frontiers in cellular neuroscience, 12, 518.

Ogawa, Y., Yamaguchi, J., Yano, M., Uchiyama, Y., & Okano, H. J. (2018). Elavl3 regulates neuronal polarity through the alternative splicing of an embryo-specific exon in AnkyrinG. Neuroscience Research, 135, 13-20.

Ogawa, Y., Kakumoto, K., Yoshida, T., Kuwako, K. I., Miyazaki, T., Yamaguchi, J., ... & Okano, H. J. (2018). Elavl3 is essential for the maintenance of Purkinje neuron axons. Scientific reports, 8(1), 1-13.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-ELAVL3 Monoclonal Antibody (16A11)

Mouse Anti-ELAVL3 Recombinant Antibody (CBFYH-0148)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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