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Mouse Anti-EPX Recombinant Antibody (2Q2224) (CBMAB-E1620-FY)

This product is mouse antibody that recognizes EPX. The antibody 2Q2224 can be used for immunoassay techniques such as: ELISA.
See all EPX antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2Q2224
Antibody Isotype
IgG1
Application
ELISA

Basic Information

Immunogen
Recognizes human eosinophil peroxidase from eosinophils among peripheral blood cells
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Eosinophil Peroxidase
Introduction
This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded preproprotein is proteolytically processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a gene cluster with other peroxidase genes on chromosome 17. Mutations in this gene result in eosinophil peroxidase deficiency.
Entrez Gene ID
8288
UniProt ID
P11678
Alternative Names
Eosinophil Peroxidase; EC 1.11.1.7; EPO; EPP; EC 1.11.1; EPX-PEN; EPXD; EPER
Research Area
Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.
Biological Process
Defense response to bacterium Source: GO_Central
Defense response to nematode Source: Ensembl
Eosinophil migration Source: Ensembl
Hydrogen peroxide catabolic process Source: UniProtKB-KW
Negative regulation of interleukin-10 production Source: Ensembl
Negative regulation of interleukin-5 production Source: Ensembl
Positive regulation of interleukin-4 production Source: Ensembl
Response to oxidative stress Source: InterPro
Cellular Location
Cytoplasmic granule. Cytoplasmic granules of eosinophils.
Involvement in disease
Eosinophil peroxidase deficiency (EPXD):
A rare abnormality without clinical symptoms characterized by decreased or absent peroxidase activity and decreased volume of the granule matrix in eosinophils.

Choi, K. M., Joo, M. S., Kang, G., Woo, W. S., Kim, K. H., Jeong, S. H., ... & Park, C. I. (2021). First report of eosinophil peroxidase in starry flounder (Platichthys stellatus): Gene identification and gene expression profiling. Fish & Shellfish Immunology, 118, 155-159.

Wright, B. L., Doyle, A. D., Shim, K. P., Pai, R. K., Barshow, S. M., Horsley-Silva, J. L., ... & Dellon, E. S. (2021). Image analysis of eosinophil peroxidase immunohistochemistry for diagnosis of eosinophilic esophagitis. Digestive diseases and sciences, 66(3), 775-783.

Germic, N., Fettrelet, T., Stojkov, D., Hosseini, A., Horn, M. P., Karaulov, A., ... & Simon, H. U. (2021). The release kinetics of eosinophil peroxidase and mitochondrial DNA is different in association with eosinophil extracellular trap formation. Cells, 10(2), 306.

Hasan, S. H., Taylor, S., Garg, S., Buras, M. R., Doyle, A. D., Bauer, C. S., ... & Schroeder, S. (2021). Diagnosis of pediatric non-esophageal eosinophilic gastrointestinal disorders by eosinophil peroxidase immunohistochemistry. Pediatric and Developmental Pathology, 24(6), 513-522.

Sánchez, J., Sánchez, A., Munera, M., Garcia, E., Lopez, J. F., Velásquez-Lopera, M., & Cardona, R. (2021). Presence of IgE autoantibodies against eosinophil peroxidase and eosinophil cationic protein in severe chronic spontaneous urticaria and atopic dermatitis. Allergy, asthma & immunology research, 13(5), 746.

Roth-Carter, Q. R., Luo, H., Ochkur, S. I., Jacobsen, E. A., Datena, M., Fryer, A. D., ... & Jacoby, D. B. (2020). Eosinophil peroxidase induces inflammation in a mouse model of dermatitis. bioRxiv.

Percopo, C. M., Krumholz, J. O., Fischer, E. R., Kraemer, L. S., Ma, M., Laky, K., & Rosenberg, H. F. (2019). Impact of eosinophil‐peroxidase (EPX) deficiency on eosinophil structure and function in mouse airways. Journal of leukocyte biology, 105(1), 151-161.

Colon, S., Luan, H., Liu, Y., Meyer, C., Gewin, L., & Bhave, G. (2019). Peroxidasin and eosinophil peroxidase, but not myeloperoxidase, contribute to renal fibrosis in the murine unilateral ureteral obstruction model. American Journal of Physiology-Renal Physiology, 316(2), F360-F371.

Lal, D., Wright, B. L., Shim, K. P., Zarka, M. A., Lee, J. J., Chang, Y. H., ... & Rank, M. A. (2019). Eosinophil peroxidase, GATA3, and T-bet as tissue biomarkers in chronic rhinosinusitis. Journal of Allergy and Clinical Immunology, 143(6), 2284-2287.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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