Mouse Anti-ETV7 Antibody (1A6) (CBMAB-0365-YC)

Provided herein are mouse monoclonal antibodies against Human ETV7. The antibody clone 1A6 can be used for immunoassay techniques, such as IP, WB and MA.
See all ETV7 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

1A6

Antibody Isotype

IgG2b

Application

IP, WB, MA

Basic Information

Immunogen

Recombinant protein

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

ETV7

Introduction

ETV7 (ETS variant 7) belongs to the ETS family of transcription factors, which is a large group of evolutionarily conserved transcriptional regulators that play an important role in a variety of cellular processes throughout development and differentiation, and are involved in oncogenesis as well. ETV7 is predominantly expressed in hematopoietic tissues.

Entrez Gene ID

51513

UniProt ID

Q9Y603

Alternative Names

TEL-2; TEL2

Research Area

Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Isoform A does not seem to have a repressor activity. Isoform C does not seem to have a repressor activity.

Biological Process

Animal organ morphogenesis Source: ProtInc
Cell differentiation Source: GO_Central
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Transcription by RNA polymerase II Source: ProtInc

Cellular Location

Nucleus

References

Froggatt, H. M., Harding, A. T., Chaparian, R. R., & Heaton, N. S. (2021). ETV7 limits antiviral gene expression and control of influenza viruses. Science signaling, 14(691), eabe1194.

Li, H., Zhang, Y., & Zheng, S. (2021). Comprehensive Analysis Identified ETV7 as a Potential Prognostic Biomarker in Bladder Cancer. BioMed research international, 2021.

Froggatt, H. M., Harding, A. T., Heaton, B. E., & Heaton, N. S. (2020). ETV7 limits antiviral gene expression and control of SARS-CoV-2 and influenza viruses. bioRxiv, 851543.

Qu, H., Zhao, H., Zhang, X., Liu, Y., Li, F., Sun, L., & Song, Z. (2020). Integrated analysis of the ETS family in melanoma reveals a regulatory role of ETV7 in the immune microenvironment. Frontiers in immunology, 11, 612784.

Alessandrini, F., Pezzè, L., Menendez, D., Resnick, M. A., & Ciribilli, Y. (2018). ETV7-mediated DNAJC15 repression leads to doxorubicin resistance in breast cancer cells. Neoplasia, 20(8), 857-870.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-ETV7 (AA 90-341) Recombinant Antibody (CBFYE-1367)

Mouse Anti-ETV7 Recombinant Antibody (CBYJT-1245)

Mouse Anti-ETV7 (AA 90-341) Recombinant Antibody (CBFYE-1368)

Mouse Anti-ETV7 Antibody (1A1)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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